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DNA Complex Interaction of hChlR1-WT and Mutants

This study investigates DNA complex interactions of hChlR1-WT and mutants hChlR1-K897del and hChlR1-K50R using a 120-mer dT with 44 bp. Results suggest varying binding affinities with Mg2+ concentration changes.

aileen-palmer
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DNA Complex Interaction of hChlR1-WT and Mutants

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  1. Fig. S4 A hChlR1-WT (nM) 0 0.15 0.3 0.6 1.2 2.4 4.8 9.6 19.2 * * * * and/or

  2. B Fig. S4 (cont’d) hChlR1-WT (nM) 0 0.3 0.6 1.2 2.4 4.8 9.6 19.2 hChlR1 : DNA complex 120 mer dT * 44 bp * hChlR1-K897del (nM) 0 0.3 0.6 1.2 2.4 4.8 9.6 19.2 hChlR1 : DNA complex 120 mer dT * 44 bp * hChlR1-K50R (nM) 0 0.3 0.6 1.2 2.4 4.8 9.6 19.2 hChlR1 : DNA complex 120 mer dT * 44 bp *

  3. Fig. S4 (cont’d) C Mg2+ (mM) NE 0 0.06 0.125 0.25 0.5 1 2 * * * * * * * * and/or hChlR1-WT(2.4nM) hChlR1-WT D RECQ1 Protein (nM) 0 0.15 0.3 0.6 1.2 2.4 4.8 9.6 19.2 19.2 and/or

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