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Transmission and Reflective Ultrasound Images using PE-CMOS Sensor Array Chu Chuan Liu 1,2 , Shih-Chung B. Lo 1 , Matthew T. Freedman 1, John Kula 3 , Bob Lasser 3 , Marvin E. Lasser 3 , Paul Wang 4 , and Yue Wang 2 1. ISIS Center, Georgetown University Medical Center, Washington, DC

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transmission and reflective ultrasound images using pe cmos sensor array
Transmission and Reflective Ultrasound Images using PE-CMOS Sensor Array

Chu Chuan Liu1,2, Shih-Chung B. Lo1,

Matthew T. Freedman1, John Kula3, Bob Lasser3, Marvin E. Lasser3 , Paul Wang4, and Yue Wang2

1. ISIS Center, Georgetown University Medical Center, Washington, DC

2. Computational Bioinformatics and Bioimaging Laboratory (CBIL),

Virginia Polytechnic Institute and State University (Virginia Tech), VA

3. Imperium Inc., Silver Spring, MD

4. MRI Center, Howard University, Washington DC

contents
Contents
  • New piezoelectric CMOS sensor array (Model I400).
  • Dynamic range of the I400 chip.
  • Preliminary studies using transmission and reflective geometries :
  • Finger images.
  • Breast phantom images (CIRS model 52).
  • Bone fractures (reflective mode)
  • Small animal studies (heart motion & body).
transmission ultrasound data acquisition
Transmission Ultrasound – Data Acquisition

PC

Image Capture

Large unfocused

Compound Lens

source

DSP

Frame

Grabber

User Interface/

Delay for Water

Image

Path

Processing

Sensor array

Target (breast with lesion)

Pulser

PC

Controlled

hybrid microelectronic sensor array
Hybrid Microelectronic Sensor Array

Bond Wires

Die

Piezoelectric Coating

PGA Carrier

Schematic of the array

A 128 × 128 assembled array

a compact laboratory system
A Compact Laboratory System

Detecting System

Component

Transducer

reflective system design
Reflective System Design

Transducer

Sensor (inside)

Beam Splitter

use a step wedge for the evaluation of dynamic range
Use a Step Wedge for the Evaluation of Dynamic Range

Attenuation : 0.7dB/cm/MHz +- 0.07dB/cm/MHz

dynamic range 5mhz
Dynamic Range (5MHz)

11.6 dB

16.1

dB

20.6 dB

25.1dB

29.6dB

34.1dB

38.6dB

43.1dB

47.6dB

52.1 dB

56.6dB

61.1dB

I100 chip

(average 32)

I400 chip

(1 frame)

We found that the dynamic range of the I400 sensor is about 70dB.

finger images 5mhz
Finger Images (5MHz)

Distal interphalangeal joint

Tendon of pollicis longus

Extensor tendon

breast cysts and masses 7 5mhz
Breast Cysts and Masses (7.5MHz)

An old CIRS phantom (model 52)

bone fractures experiment 5mhz
Bone Fractures Experiment (5MHz)

Reflective ultrasound setup

bone fractures reflective mode

A

A

C

C

B

B

A

A

B

B

St

St

D

D

A

A

C

C

B

B

C

C

D

D

Sb

Sb

D

D

~500 mm

Bone Fractures (Reflective Mode)
mouse body heart motion movies
Mouse Body & Heart Motion Movies
  • Three movie shows:
  • Whole mouse body movie operated at 5 MHz.
  • Mouse heart motion movie operated at 5 MHz.
  • Mouse heart motion movie operated at 3.5 MHz.
conclusions
Conclusions
  • The new ultrasound sensor array (I400) shows a dynamic range up to 70dB.
  • The system (transmission and reflective modes) has spatial resolution up to 350mm.
  • In the study of mice (with fur), we found that the heart motion can be captured. Lower frequency (3.5MHz) ultrasound shows better penetration for the chest region of the mouse. Both frequency and power were not optimized for the chest and abdomen regions.
  • We are developing image composition method (hardware & software) to integrate images for a large FOV.