Food sources of saturated fat and risk of heart disease
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Food Sources of Saturated Fat and Risk of Heart Disease. Dariush Mozaffarian, MD DrPH Division of Cardiovascular Medicine, BWH/HMS Department of Epidemiology, HSPH Saturated or Not: Does Type of Fat Matter? Harvard School of Public Health April 25, 2014. Dietary Fats & Blood Lipids. SFA.

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Food Sources of Saturated Fat and Risk of Heart Disease

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Food sources of saturated fat and risk of heart disease

Food Sources of Saturated Fat and Risk of Heart Disease

Dariush Mozaffarian, MD DrPH

Division of Cardiovascular Medicine, BWH/HMS

Department of Epidemiology, HSPH

Saturated or Not: Does Type of Fat Matter?

Harvard School of Public Health

April 25, 2014


Food sources of saturated fat and risk of heart disease

Dietary Fats & Blood Lipids

SFA

SFA

MUFA

No Δ ApoB

PUFA

∆ LDL-C, mmol/L

∆ HDL-C, mmol/L

MUFA

PUFA

SFA

∆ Triglycerides, mmol/L

∆ Total:HDL-C Ratio

MUFA

MUFA

SFA

PUFA

PUFA

Meta-analysis of 60 feeding RCTs. Mensink & Katan, AJCN 2003


Food sources of saturated fat and risk of heart disease

Dietary Fats & CHD Events

Chowdury et al, Annals Intern Med 2014


Food sources of saturated fat and risk of heart disease

Saturated Fat & CHD Events

16 prospective

cohort studies from

around the world

No Significant Association

RR comparing extreme categories (highest vs. lowest) of saturated fat intake

Siri-Tarino et al, AJCN 2010


Food sources of saturated fat and risk of heart disease

Food Sources of Saturated Fat in the US

Based on NHANES 2005-06. From USDA Dietary Guidelines 2010


Food sources of saturated fat and risk of heart disease

Food Sources: Meats & CHD

Unprocessed Red Meat (100 g/d)

RR = 1.00

(0.81, 1.23)

Processed Meat (50 g/d)

RR = 1.42

(1.07, 1.89)

Micha et al., Circulation 2010


Food sources of saturated fat and risk of heart disease

Food Sources: Meats & CVD Mortality

Total Red Meat

RR = 1.09

(0.93, 1.27)

Processed Meat

RR = 1.17

(1.02, 1.33)

O’Sullivan et al., Am J Public Health 2013


Food sources of saturated fat and risk of heart disease

Food Sources: Meats & CVD Mortality

Among 448,568 European men and women (EPIC),

including 5,556 CVD deaths

Total Red Meat (100 g/d)

RR = 1.09

(1.00, 1.18)

Processed Meat (100 g/d)

RR = 1.69

(1.37, 2.10)

Rohrmann et al., BMC Medicine 2013


Food sources of saturated fat and risk of heart disease

Food Sources: Dairy & CVD Mortality

Milk

RR = 0.96

(0.81, 1.13)

Cheese

RR = 1.00

(0.81, 1.24)

O’Sullivan et al., Am J Public Health 2013


Food sources of saturated fat and risk of heart disease

Dairy Foods & Diabetes

Among 340,234 Europeans from 8 countries, with 12,403 cases of incident diabetes

P-trend=0.50

P-trend=0.06

P-trend=0.01

RR of

Diabetes

Quintiles of Consumption

Adjusted for age, sex, center, education, smoking, physical activity, alcohol intake, and consumption of

fruits, vegetables, red meat, processed meat, sugar sweetened beverages, coffee, cereals, and cerearl products.

Sluijis et al., AJCN 2012


Food sources of saturated fat and risk of heart disease

Healthy Diet Patterns & CVD Events

Randomized controlled trial among 7447 Spanish adults at higher risk

No change in saturated fat.

HR = 0.70 (0.55, 0.89)

Estruch et al. NEJM 2013


Food sources of saturated fat and risk of heart disease

Global Disease Burdens Due to Major Risk Factors in 2010

Diet high in SFA & low in PUFA

0.47

Lim et al, Lancet 2012


Food sources of saturated fat and risk of heart disease

Healthy Food Replacements


Food sources of saturated fat and risk of heart disease

Healthy Food Replacements


Food sources of saturated fat and risk of heart disease

Healthy Food Replacements


Food sources of saturated fat and risk of heart disease

Prioritizing Fat or Saturated Fat: Useful ?


Food sources of saturated fat and risk of heart disease

Preventing Chronic Diseases: Food Patterns


Food sources of saturated fat and risk of heart disease

Essential Dietary Habits for Health

EAT:

  • Seafood

  • Fruits

  • Nuts

  • Vegetables

  • Vegetable Oils

  • Whole grains

  • Yogurt

LIMIT:

  • Starches, refined grains, sugars

  • Processed Meats

  • Sweetened Drinks

  • Industrial Trans Fat *

  • Salt *

Also: Don’t smoke, turn off the TV,

get enough sleep, and be physically active.

Mozaffarian, Appel, & Van Horn. Circulation 2011


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