Lipids. CH339K. What are lipids?. Grab bag of molecular types Common link is their hydrophobicity Fats Glycerophospholipids Sphingolipids Waxes Eicosanods Steroids And other stuff. F A T T Y A C I D S.
You can’t make fatty acids where the double bond is 6 carbons or closer to the end of the molecule
In living systems, the double bonds of unsaturated fatty acids are usually cis-.
Very often – fatty acid + long-chain alcohol.
What happens if I substitute something else for a fatty acid in a fat?
Like a Phosphate?
Major component of inner mitochondrial membrane (up to 20%)
R groups usually c18:2
Major component in heart muscle membranes
Causes platelet aggregation and vasodilation (inflammatory mediator).
Important to the process of hemostasis.
Important in implantation.
Concentration of 10-12 M causes life threatening inflammation of the airways (asthma-like symptoms).
Toxins such as fragments of destroyed bacteria induce synthesis of PAF
causes drop in blood pressure
reduced volume of blood pumped by the heart
shock and possible death.
Sphingosine by itself
Defective ganglioside digestive enzymes cause disease
As a child with Tay-Sachs grows older, he or she may become blind, mentally retarded, paralyzed, and unresponsive to the environment. The child also may have seizures, difficulty swallowing, and difficulty breathing. Children with Tay-Sachs disease rarely live beyond 4 or 5 years of age.
Mutation in lysosomal enzyme Hexosaminidase A
Bile salts are steroid acids
Erythrocyte Membrane – differences between inner and outer layers