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Depression

Depression. Tricyclic (TCA) and Selective serotonin reuptake inhibitor (SSRI). Ali Gomez Wri 116 Fall 2013. “I never considered that an underlying condition was hampering my ability to handle the stress. I thought, this is just how life is. ”. What is Depression?. Disorder

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Depression

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  1. Depression Tricyclic (TCA) and Selectiveserotoninreuptakeinhibitor (SSRI) Ali Gomez Wri 116 Fall 2013

  2. “I never considered that an underlying condition was hampering my ability to handle the stress. I thought, this is just how life is. ”

  3. What is Depression? • Disorder • Interferes with daily activity • Causes pain for both the person with it as well as people around them • Interferes with person's ability to work, sleep, study, eat, and enjoy once-pleasurable activities • Mood changes

  4. Treatment: DRUG THERAPY • Many different forms • Most common ones: • Tricyclic Antidepressant (TCA) • Selective Serotonin Reuptake Inhibitor (SSRI) • Both given in pill form • Effects the nerves • Dosage depends on age and level diagnosed

  5. Tricyclic Antidepressant • Earliest prescribed • Main goal: make chemical changes in the brain = slow reuptake • Reuptake: when a shock leaves the brain and is absorbed back into the nerve cell in brain • Shock = neurotransmitters • The chemicals are usually serotonin and norepinephrine • Side effects: • weight gain, dry mouth, constipation, drowsiness, and dizziness.

  6. Shock occurs (shout: dinner) • Serotonin are realeased (stand up) • Serotonin goes through the gap (walk to table) • Enters receptors = (sit down and talk about day) • Reuptake slow(go back to living room) • Black certain recepters = side effects

  7. Selective Serotonin Reuptake Inhibitor (SSRI) • Most prescribed anti- depressants • ease symptoms of moderate to severe depression • are safer • cause fewer side effects than other types of antidepressants • Side effects: • Nausea, Nervousness, agitation or restlessness, Dizziness • Reduced sexual desire or difficulty reaching orgasm or inability to maintain an erection (erectile dysfunction) • Drowsiness, Insomnia, Weight gain or loss, Headache, Dry mouth, Vomiting, Diarrhea

  8. http://www.youtube.com/watch?v=sc-4zhqViQ4 http://www.youtube.com/watch?v=sc-4zhqViQ4

  9. Study: Efficacy and Tolerability of Tricyclic Antidepressants and SSRIs Compared With Placebo for Treatment of Depression in Primary Care • Bruce Arroll, MBChB, PhD, Department of General Practice and Primary Health Care, University of Auckland, Private Bag 92019, Auckland, NZ • Methods: • Adults • TCA, SSRI, and Placebo (control treatment) • Primary care patients • Low dose (75mg and 100 mg) • 10 studies • 2-6 weeks

  10. Results • 3 SSRI and placebo • 2 TCA and Placebo • 56% - 70% responded well to active treatment • 42% - 47% responded to Placebo • Relative Risk for withdrawal • 2.35 for TCA • Non for SSRI • Relative Risk (less likely to occur an experimental group than in controld group) • 1.26 for TCA • 1.37 for SSRI

  11. Conclusion • Both TCA and SSRI are effective • Low dose are effective in primary care • TCA and SSRI are more effective than placebo

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