1 / 20

Protein Structure

Protein Structure. Fall 2011 Aaron Zampaglione. Protein Fold. Rossmann Fold. Protein Domains (Folds). Four main classes: All -α All- β α+ β α /β ( Membrane and cell surface proteins and peptides) (Small proteins). All-α. The lone helix The helix-turn-helix motif

zorion
Download Presentation

Protein Structure

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Protein Structure Fall 2011 Aaron Zampaglione

  2. Protein Fold Rossmann Fold

  3. Protein Domains (Folds) Four main classes: • All-α • All-β • α+β • α/β • (Membrane and cell surface proteins and peptides) • (Small proteins)

  4. All-α • The lone helix • The helix-turn-helix motif • The four-helix bundle • Helix-helix packing

  5. All-β • β sandwiches and β barrels • Up-and-down antiparallel β sheets • β-propellors • β-trefoils • β-Helix

  6. α+β • Bacterial and mammalian pancreatic ribonucleases • Lysozome • Ubiquitin

  7. α/β • α/βhorseshoe • α/βbarrels beta-alpha-beta

  8. Motif

  9. Structural Motifs • β-α-β • β-hairpin • Greek Key • Helix-Loop-Helix (HLH) • Helix-Turn-Helix (HTH) • Leucine Zipper • Psi-loop • Zinc Finger

  10. β-α-β Motif

  11. β-hairpin Motif

  12. Greek Key Motif

  13. Helix-Loop-Helix (HLH) Motif

  14. Helix-Turn-Helix (HTH) Motif

  15. Leucine Zipper Motif

  16. Psi-loop Motif

  17. Zinc Finger Motif

  18. Biology Workbench • Protein Tools • Alignment Tools • Structure Tools http://workbench.sdsc.edu

  19. Additional Tools • CDART (Motifs) • http://www.ncbi.nlm.nih.gov/Structure/lexington/lexington.cgi?cmd=rps • PROSITE (Motifs) • http://prosite.expasy.org/cgi-bin/prosite/prosite-list.pl • SCOP (Structure) • http://scop.mrc-lmb.cam.ac.uk/scop • CATH (Structure) • http://www.cathdb.info

  20. References • Expasy. (1999). Tertiary Protein Structure and folds. Retrieved 08 30, 2011, from Expasy: http://swissmodel.expasy.org/course/text/chapter4.htm • Karadaghi, S. (2011). Protein Domains. Retrieved 08 30, 2011, from Protein Structures: http://www.proteinstructures.com/Structure/Structure/protein-domains.html • …

More Related