INCREASED OXIDATIVE STRESS REALTED TO USE OF SMOKELESS TOBACCO”MARAS POWDER”. Elif Köse¹ , Hakim Çelik², Özlem Yazıcıoğlu Moçin ³ ¹Ceylanpinar /Sanliurfa Tuberculosis Dispansery, Sanliurfa ²Harran University School of Medicine Biochemistry Department, Sanliurfa
Elif Köse¹ , Hakim Çelik², Özlem Yazıcıoğlu Moçin³
¹Ceylanpinar /Sanliurfa Tuberculosis Dispansery, Sanliurfa
²Harran University School of Medicine Biochemistry Department, Sanliurfa
³ TRMH Sureyyapasa Chest Diseases and Chest Surgery Training Hospital, Istanbul.
A- Normal Biologic Processes:
1. Respiration with Oxygen,
2. Catabolic and Anabolic Reactions
B- Conditions causing Oxidative Stress
C- Period of Ageing
e-e-+2H+ e-+H + e-+H +
O2 O2-H2O2 OH- H2 O
3. Single Oxygen
ROS TOBACCO”MARAS POWDER”
LOSS OF MEMBRANE
INACTIVATION OF ENZYMES
A) Intracellular Antioxidants
B) Membrane Antioxidants
C) Extracellular Antioxidants
Transferrin, Lactoferrin, Haptoglobulin, Seruloplasmin
The lungs have strong and diffuse antioxidant system in intracellular and extracellular level:
It has been detected that Maras Powder, which has been used as an alternative for tobacco, has adverse effects for human health:
Worsening in lung functions like in case of tobacco,
Oral cancer risk,
( mean value of age 30,08 ±6,69), no history of tobacco use.
OXIDATIVE STRESS INDEX(OI)= TOL/TAC
There was a significant difference between Maras powder group, smokers group and control group (p<0.05).
There was no significant difference between Maras powder group and smokers group(p>0.05).