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Computer Generated Vasculature. Laboratory for Product and Process Design Undergraduate: Dexter Teng Mentors: Brian Sweetman & Andreas Linninger Date: February 4th, 2010. Motivation.

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Computer generated vasculature

Computer Generated Vasculature

Laboratory for Product and Process Design

Undergraduate:Dexter Teng

Mentors:Brian Sweetman & Andreas Linninger

Date:February 4th, 2010


Motivation
Motivation

  • MAIN GOAL: Reconstruct accurate model of brain vasculature using Constrained Constructive Optimization (CCO) algorithm.


Significance
Significance

  • Contribute to an overarching goal of constructing a model to better quantify brain physics interaction between:

    • CSF (Ventricular system)

    • Blood (Vascular system)

    • And Brain Tissue…

  • … in order to improve treatment and diagnosis of CNS diseases.


Preliminary goal goal 1
Preliminary Goal (Goal 1)

  • Understand how to reconstruct a vascular system with simple constraints using CCO algorithm

    • 1. Literature search.

    • 2. Understand CCO algorithm.

      • Review vector algebra

    • 3. Choose & develop data structure.

    • Timeline: Week 1-5 (5)


2 what is cco algorithm

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2. What is CCO algorithm?

  • A set of rules based on physiological laws for pseudo-stochastic growth of a fractal system [in this case our system is the vasculature].

    • Know: # of terminal points, bifurcation exponent (for radii shrinkage), perfusion pressure/flow, terminal pressure/flow, viscosity of blood and size of medium (circle, heart, brain etc)

  • More work needs to be done.

    • Review Smit’s work.


3 data structure
3.Data Structure

  • Important - organization of nodes is the most important aspect of CCO. Versatility is required because of the nature of CCO.

    • Requires that nodes are traversable, removeable and readjustable

  • Possible Data Structures

    • Arrays

    • Singly linked-lists

    • Doubly linked-list

    • Binary Tree

  • Programming needs to be done.


Semester goals
Semester Goals

  • Goal 2: Reconstruct a small 2-D vasculature in circle

    • 1. Program CCO algorithm on MATLAB

      • 1.1 Have algorithm compatible with data structure code.

    • 2. Begin technical report.

    • Weeks 6-8 (3)




  • Questions? Comments?

  • Bibliography:

    • Slide 1; picture: Schreiner, Wolfgang, Rudolf Karch, Friederike Neumann, Bruno K. Podesser et al. "Fractal Properties of Perfusion Heterogeneity in Optimized Arterial Trees: A Model Study." The Journal of General Physiology (2003): 311. Print.

    • Slide 5; picture: Smit Naik

    • Slide 6; picture: Wikipedia


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