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Computer Generated Vasculature

Computer Generated Vasculature. Laboratory for Product and Process Design Undergraduate: Dexter Teng Mentors: Brian Sweetman & Andreas Linninger Date: March 11, 2010. Motivation. MAIN GOAL: Generate a model cerebral vasculature based on physiology. Significance.

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Computer Generated Vasculature

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  1. Computer Generated Vasculature Laboratory for Product and Process Design Undergraduate:Dexter Teng Mentors:Brian Sweetman & Andreas Linninger Date:March 11, 2010

  2. Motivation • MAIN GOAL: Generate a model cerebral vasculature based on physiology.

  3. Significance • Contribute to an overarching goal of constructing a model to better quantify physical interaction between: • CSF (Ventricular system) • Blood (Vascular system) • And Brain Tissue… • … in order to improve treatment and diagnosis of CNS diseases.

  4. Asupp ibif iconn inew iroot Asupp ibif iconn inew The CCO algorithm • A set of rules based on physical laws and restrictions for random growth of a vasculature.

  5. Preliminary Goal (Goal 1) • Understand how to reconstruct a vascular system using CCO algorithm • 1. Literature search. • 2. Understand CCO algorithm. • 3. Start technical report. Completed • Timeline: Week 1-6 (6)

  6. Goal 2: Reconstruct a small 2-D vasculature in circle • 1. Literature search on capillaries. • 2. Desk tests • 4. Begin preliminary coding. • 5. Reproduce vasculature. Completed 75% • Weeks 6-10 (5)

  7. Update on Goal 2 • We can reproduce a vasculature with hardcoded points that performs an optimization. • Values match up well with desk test values. • Report is developing well. Need to document code. • Literature search on capillaries completed. Reviewing literature.

  8. Goal 3: Reconstruct 3-D Vasculature in sphere • 1.Literature search on relevant topics • 2.Understand methods. • 3.Add onto technical report. • 4.Implement into code. • Weeks 10-13 (4)

  9. Goal 4: Reconstruct a 3-D vasculature in a model brain. • Between Ventricular system and Brain Tissue • Implement into code • Add onto technical report. • 13-16 (4)

  10. Questions / Comments? • Reference/Pictures: • Slide 1; picture: Schreiner, Wolfgang, Rudolf Karch, Friederike Neumann, Bruno K. Podesser et al. "Fractal Properties of Perfusion Heterogeneity in Optimized Arterial Trees: A Model Study." The Journal of General Physiology (2003): 311. Print. • Slide 5; picture: Smit Naik • Slide 6; picture: Wikipedia

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