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ICAS: CTOS 2005 Review of Studies. U.S. NCI-funded Intergroup. ICAS: Mission and Vision. NCI-funded coalition of North American cooperative oncology groups with focus in Sarcoma Research

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icas ctos 2005 review of studies

ICAS:CTOS 2005 Review of Studies

U.S. NCI-funded Intergroup

icas mission and vision
ICAS: Mission and Vision
  • NCI-funded coalition of North American cooperative oncology groups with focus in Sarcoma Research
  • Leverage fixed infrastructures ofSWOG, CALGB, ECOG, and NCI-Canadato advance publicly-funded sarcoma research
what is the role of icas
What is the Role of ICAS?
  • Differentiation of work from other smaller groups without NCI funding and with more restricted focus of activities
  • Where does national and international scale really need to be applied to advance research?
strengths for nationally funded sarcoma research effort
Strengths for Nationally Funded Sarcoma Research Effort
  • Very large scale effectiveness studies
  • Casting a very broad net to include the entire continent of physicians and patients
  • Legitamacy and stability ofpublic sector funding through NCI
review of icas studies
Review of ICAS Studies
  • S0033: randomized GIST testing Imatinib 400 v. 800
    • continuing molecular studies
    • survival long term
    • other sub-studies in progress
icas studies metastatic disease

ICAS STUDIESMetastatic Disease

ICAS #SarcomaTargetAgent

S0330* MPNST EGF-R erlotinib

S0345 DFSP PDGF-R imatinib

S0346 Synovial HER2 trastuzumab

S0505 All STS VEGFR+ sorafenib

* First Stage accrual goal reached

icas studies metastatic disease1

ICAS STUDIESMetastatic Disease

ICAS #SarcomaTargetInhibitor

S0423 Chondro MTAP pemetrexed

S0502 GIST KIT/PDGFR Imatinib

VEGF bevacizumab

S0416 (COG) GIST (Pedi-AYA) KIT/PDGFR imatinib

the future of icas
The Future of ICAS
  • Choose carefully which trials require full scope of national group mechanism
  • Optimize efficiency for participation through inclusive investigator registration mechanism
    • test the function and promise of theClinical Trials Support Unit of NCI)
z9031
Z9031

A randomized trial of preoperative radiation plus

surgery versus surgery alone for localized primary

retroperitoneal STS. P.W.T. Pisters, MD

Arm 1:Surgery

Patients with primary STS of the retroperitoneum or pelvis

R

A

N

D

O

M

I

Z

E

Arm 2:XRT plus Surgery

CTSU !!!

A C O S O G

slide10
Z9001

Phase III randomized double-blind study ofadjuvant Imatinib versus placebo in patientsfollowing resection of primary GIST.Study Coordinator: Ronald DeMatteo, MD

Primary GIST > 3 cm

Successful

Use of CTSU

Decentralized

Registrations

Complete Gross Resection

Tumor KIT +

Randomize

Placebo

x 1 yr

Imatinib

x 1 yr

acosog in development
ACOSOG in Development

Phase II evaluation of PET imaging as a predictor of response to neoadjuvant treatment for STS. Edward Cheng, MD (collaborative effort with ACRIN)

Neoadjuvant Rx

FDG-PET scan, routine staging studies

(MRI and CT)

Biopsy-

Confirmed

STS

Repeat FDG-PET

Wide local excision, histologic assessment of necrosis

A C O S O G

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