CIHR team grant in HIV vaccine discovery: novel mechanisms and strategies of protection University of Toronto KAVI University of Nairobi. Presenter: Dr Julius Oyugi. HIV Vaccine Team. University of Toronto Mario Ostrowski [PI] Tania Watts Jen Gommerman Goetz Erhardt Rupert Kaul
Presenter: Dr Julius Oyugi
University of Toronto
University of Nairobi
Theme 1: Optimizing CD8 T cell memory for prophylactic or therapeutic immunization.
Theme #2: Optimizing and targeting mucosal
Goal is to determine whether a VZV based vaccine could;
Team member Philpott is Nod expert
Test ability of candidate NLR agonists to enhance antibody responses at the mucosal level.
Progress: Have begun testing Nod 2 agonist (MDP) and a novel nod agonist (AHL) in a DNA vaccine and protein vaccine approach using gp120 in Balb/C mice.
Progress: Obtained Envclade A and C during early infection