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Phosphotransferase System

A novel sugar-phosphorylating system in Escherichia coli has been discovered several years ago. The unique features of this phosphotransferase system (PTS) consist of the use of phosphoenolpyruvate (PEP) as the phosphoryl donor for sugar phosphorylation and the presence of three essential catalytic entities, termed Enzyme I, Enzyme II and HPr (heat-stable, histidine-phosphorylatable protein).

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Phosphotransferase System

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  1. Phosphotransferase System A novel sugar-phosphorylating system in Escherichia coli has been discovered several years ago. The unique features of this phosphotransferase system (PTS) consist of the use of phosphoenolpyruvate (PEP) as phosphorylation and the presence of three essential catalytic entities, termed Enzyme I, Enzyme II and HPr (heat-stable, histidine-phosphorylatable protein). Established primary functions of the system include sugar reception, transport and phosphorylation, whereas secondary functions include a lot of ramifications of metabolic and transcriptional regulation. the phosphoryl donor for sugar PTS auxiliary proteins such as the fructose repressor, FruR, and the Mlc transcription factor are believed to control transcription of the PTS genetic apparatus as well as of genes encoding central pathways of carbon metabolism in enteric bacteria. Glycolysis, the Krebs cycle, electron transport, the glyoxylate shunt, gluconeogenesis, and possibly the Entner-Doudoroff pathway are all included in these pathways. Genetic evidence has suggested that other processes including the net production of carbon and energy storage sources such as poly-β-hydroxybutyrate and the control of σ -dependent transcription of nitrogen metabolism genes in numerous Gram-negative bacteria are also controlled by the PTS.

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