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Cardiomyopathies. Puja Chopra October 27, 2011 PGY-2 . Thanks To Dr. Margriet Greidanus !. Objectives. Hypertrophic Cardiomyopathy Obstructive Treatment EKG Dilated Cardiomyopathy Etiologies Treatment Restrictive Cardiomyopathy Etiologies Constrictive pericarditis. Case.

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Cardiomyopathies


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    1. Cardiomyopathies Puja Chopra October 27, 2011 PGY-2

    2. Thanks To Dr. MargrietGreidanus!

    3. Objectives • Hypertrophic Cardiomyopathy • Obstructive • Treatment • EKG • Dilated Cardiomyopathy • Etiologies • Treatment • Restrictive Cardiomyopathy • Etiologies • Constrictive pericarditis

    4. Case 56 YO F, post cardiac arrest Hx. Waiting surgery for HCM

    5. Hypertrophic Cardiomyopathy • A refresher

    6. Obstruction: • Ventricle size is small, mitral valve contacts the ventricle • Venturi effect high flow through obstruction

    7. Atrial dilation and back flow into the pulmonary vasculature • Dyspnea with increased oxygen consumption (90%) • Reduced Cardiac Output • Syncope (30%) • Thickened ventricular arterioles with reduced lumen • Angina (30%)

    8. P/E: • LVH • Sustained PMI • Irregularly Irregular Pulse • Mid systolic ejection murmur

    9. Back TO the Case: HR 140, RR(intubated and bagged at 12) Sats100%, BP 95/60

    10. (Case 1) Normal sinus rhythm with large-amplitude QRS complexes consistent with LVH and nonspecific T-wave abnormality. Deep narrow Q waves are also present in the lateral leads I, aVL, V5, and V6.

    11. Normal sinus rhythm with LVH and deep narrow Q waves in the lateral leads I, aVL, V5, and V6.

    12. Normal sinus rhythm with LVH and deep narrow Q waves in the lateral leads I and aVL.

    13. EKG • LVH: high voltage R waves in the anterolateral leads (V4, 5, 6, I and avL) • Deep and narrow Q waves can be seen in the inferior leads and in the lateral leads (over the septum) (most specific findings)

    14. Treatment

    15. Beta Blockers! • Prolongs time in diastole • Reduces inotropic demand • Vasopressors: • - Increased SVR reduces venturi effect • Avoid Preload Reduction Agents: • Diuretics • Nitroglycerine • Nitropursside • Avoid Inotropic Agents

    16. Surgical Mymectomy: • This is reserved for patients with a high outflow tract obstruction (>50 mmHg) and those that have failure to medical management • 90% of patients have improvement in their outflow gradient with persistent symptomatic improvement at 5 years • Reduced amount of SCD in those with surgical mymectomy

    17. Anticoagulation - 6% rate of strokes in these patients

    18. 25 yo male syncope with exercise 25 yo male light headed post exercise 30 yo male chest pain with exercise

    19. 23% of patients had an appropriate discharge at follow-up period of 3 years

    20. Take Home • Hypertrophic Crisis: • Beta blocker • No positive intropic agents • ECG • LVH • Q waves in lateral and inferior leads • A. Fib • Stroke Risk: Anticoagulate

    21. 63 YO female brought to ED with central crushing chest pain and shortness of breath

    22. On Exam: Pulmonary edema • Blood pressure: 70/40 • ?Management

    23. 35 YO female, unwell Respiratory Distress Unable to speak full sentences Sitting up ?Asthma Exacerbation HR: 130, BP 95/67, 88% 15 L non re-breather

    24. But wait….. She had a baby 1 week ago!

    25. DDX of Shock

    26. Cardiac failure in the last month of pregnancy or within the five months post partum • No determinable cause of the heart failure • No heart disease before the onset of the last month of pregnancy • LV dysfunction seen on echocardiogram

    27. Dilated Cardiomyopathy • Another Refresher

    28. Etiologies: • Toxins • Ethanol, • Chemotherapeutic Agents, • Antiretrovial agents, • Cobalt, Lead, Cocaine, Mercury • Metabolic • Nutritional: Thiamine, selenium, carnitine • Endocrine: Hypothyroid, acromegaly, thyrotoxicosis, cushings, pheochromocytoma, Diabetes • Inflammatory or Infections: • Collagen Vascular Disesae: Sclerodermia, lupus, Sarcidosis • Peripartum • Infectious: • Viral Myocarditis: Parvovirus B19, Herpes, coxsackievirus, influenza virus, adenovirus, HIV • Chagas Disease: Protozoa (leading cause in SA and Central America) • Lymes Disease • Neuromuscular: • Muscular Dystrophies • Freidreich’s ataxia • Tachycardia • Familial • Stress Induced • Idiopathic

    29. Back to the Case • Treatment: • A • B • C • Future Pregnancies • Complications • ?anti-coagulation

    30. Treatment • Identify the cause of the cardiomyopathy and determine what can be reversed or prevented • Treatment goals include: • Prevention of progression • Prolonging survival by targeting the poor prognostic indexes • Symptomatic treatment • Preventing complications: • CHF • SCD approx 12% of patients will die suddenly • VTE Clinical predictors of poor prognosis: • Syncope • S3 gallop • RHF on exam • AV block, BBB (note that an av block in an idependent risk factor for death) • Elevated creatinine • Cardiothoracic ratio • EF less than 35%

    31. Take Home • Takotsubo Cardiomyopathy • 10 to 15% have LV outflow obstruction • Treat like CHF

    32. Restrictive Cardiomyopathy • Amyloidosis • Sarcoidosis • Hemachromatosis • Scleroderma • Neoplastic • Cardiac Infiltration • Radiation Heart Disease • Fabry’s Disease • Gaucher’s Disease • Idiopathic

    33. Restrictive Cardiomyopathy vs Constrictive Pericarditis