Alumina fibers in orthopedics implant osteoblast adhesion application
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ALUMINA FIBERS IN ORTHOPEDICS IMPLANT: Osteoblast Adhesion Application. Dr.Hasmaliza Mohamad Ruzainah Abdullah School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, 14300 Nibong Tebal, Pulau Pinang, Malaysia. Alumina (Al 2 O 3 ) .

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ALUMINA FIBERS IN ORTHOPEDICS IMPLANT: Osteoblast Adhesion Application

Dr.Hasmaliza Mohamad

Ruzainah Abdullah

School of Materials and Mineral Resources Engineering,

Universiti Sains Malaysia,

14300 Nibong Tebal,

Pulau Pinang, Malaysia


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Alumina (Al2O3)

Alumina is an important engineering material for high temperature industries.

Properties :

  • High strength and modulus.

  • Resistance to attack by molten metals and non-oxide materials.

  • Chemical inertness in both oxidizing and reducing atmosphere.

  • Low thermal conductivity and good electrical insulation


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Biomedical application of Al2O3

  • Dental Implant

  • Bone implant

    • Joint replacement: Knee prostheses, ankle

    • joint, shoulders and fingers.

    • Implant adhesion: Osteoblast adhesion


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Objectives

  • To increase the activities of bone cells on the surface of material used in the design of orthopedic implants.

  • Enhanced functions of osteoblasts


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Previous study:

  • Frequently, problems with orthopaedic implants occur owing to either loosening of the implant, osseo-degradation of bone surrounding the implant or hypersensitivity of the patient to the particular metal

  • Hydroxyapatite-coated implants have been successful for the most part. It has been found that bone apposition on the surface of porous hydroxyapatite-coated implants is better than that on metallic porous coatings


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Previous study: (cont..)

  • However, numerous problems are still encountered with these approaches. For example, the average lifetime of hydroxyapatite-coated implants needs improvement, owing to high solubility rates that can lead to degradation of the coating and loosening at the bone-hydroxyapatite interface


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Present study:

  • Alumina fibers will use to increase the coating toughness

  • Electrospinning provides opportunities to manipulate and control surface area, fiber diameter, porosity and pore size of nanofiber matrices

  • Study the effect of various properties of alumina fibers on adhesion


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Synthesis of the alumina fiber

  • sol – gel  Electrospinning  press  sinter

    • The combination of sol-gel processing with electrospinning techniques will provides a versatile technique for producing ceramics nanofibers




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The aim of nanoscale alumina in osteoblast adhesion

  • Nanofiber alumina (less than 100 nm in diameter) more closely simulates the physical geometry of hydroxyapatite crystals and collagen fibers in bone that osteoblasts are accustomed to interact to.


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Advantages of alumina fibers in osteoblast adhesion:

  • Increase the toughness of HAp coating

  • Give good adhesion to implant

  • Increase the degradation rate of HAp coating