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Cling- E. coli : Bacteria on target. Harvard iGEM 2007 Ellenor Brown Stephanie Lo Alex Pickett Sammy Sambu. Kevin Shee Perry Tsai Shaunak Vankudre George Xu. The motivation. To develop a system for directing bacteria to a target of interest and effecting downstream activity.

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cling e coli bacteria on target

Cling-E. coli :Bacteria on target

Harvard iGEM 2007

Ellenor Brown

Stephanie Lo

Alex Pickett

Sammy Sambu

Kevin Shee

Perry Tsai

Shaunak Vankudre

George Xu

the motivation
The motivation

To develop a system for directing bacteria to a target of interest and effecting downstream activity

  • Bacterial targeting is necessary for spatially-specific activity in the body or in nature
  • Post-targeting activity and transmembranesignalling are the next step in engineering genetic circuits that interface extracellular and intracellular environments
slide3

The vision:Bacterial targeting

via membrane display

slide5

The vision:Intra-cellular activation

viaFec signal transduction