Supplementary Figure 2

Sep 10, 2014

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Supplementary Figure 2. A B. PSA-Cre + /Pten +/+ PSA-Cre + /Pten loxP/loxP. Age ( wks ). 20 20 30 80. Weeks.

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Supplementary Figure 2

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Supplementary Figure 2 A B PSA-Cre+/Pten+/+ PSA-Cre+/PtenloxP/loxP Age (wks) 20 20 30 80 Weeks

Supplementary figure 2

Supplementary figure 2. +/+ +/m. kb. 12. 8. M +/+ +/m m/m. 2 kb 540bp 387bp. a. b. c. d. Supplementary figure 2. Generation of Unc5b mutant mice

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Supplementary Figure 2.

Supplementary Figure 2. GUS. OsCAF1A – GUS. OsCAF1B (L) – GUS. OsCAF1G – GUS. OsCAF1H – GUS.

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Supplementary Figure 2

Supplementary Figure 2. Supplementary Figure 2 . qRT -PCR-based analysis of LPA and LPC receptor expression in ARMs and ERMS cells lines. Panel A - LPAR1, LPAR2, and LPAR3 receptors. Panel B - G2A and GPR4 receptors. Combined data from two independent experiments are shown. A. B.

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Supplementary Figure 2

Supplementary Figure 2. A. B.

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Supplementary Figure 2.

RCA. RVN. LCA. LVN. LCA. RVN. RJV. T. RJV. T. LVN. LJV. ARSA. E. LJV. TR. E. LSA. ARSA. TR. LSA. RCA. RSV. LSV. RSV. LSV. LBV. LBV. RL. LL. RL. LL. TD. H. H. Supplementary Figure 2.

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Supplementary figure 2

Supplementary figure 2 PCA analysis of all the different cell lines used in the microarray experiments revealing three distinct sub groups ; translocation positive RMS cells (RMS, RMZ, RH3, RH40, RH41), translocation negative RMS cells (RD & RH18)and myoblasts (MYO & BIO).

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Supplementary Figure 2:

Supplementary Figure 2: Enrichment of CNVs identified in this study in pericentromeric regions. The fusion that

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Supplementary Figure 2

cd73 -/- +DSS Day 10. cd73 -/- + DSS Day 22. WT +DSS Day 10. WT +DSS Day 22. NF-  appaB p65 kDa. Supplementary Figure 2.

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Supplementary Figure 2

Sigmoidal Fits, E02 Retinotopy. All fits have adjR 2 >0.95. 1.0. 1.0. 0.9. 0.9. 0.8. 0.8. 0.7. 0.7. 0.6. 0.6. 0.5. 0.5. 0.4. 0.4. 0.3. Normal Cortex. LPZ Center. 0.3. 0.2. 0.2. 0.1. 4. 4. 6. 6. 2. 2. -4. -4. -2. -2. 0. 0. -6. -6. 0 14 28 42

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Supplementary Figure 2

Supplementary Figure 2. 14 days in culture. 21 days in culture. A. B. A. B. C. D. C. D. E. SF2.

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Supplementary Figure 2

ND. ob/ob. Supplementary Figure 2. A. IL6. TNF α. IL1 β. IL10. CXCL10. CCL5. CCL2. IL6. TNF α. IL1 β. IL10. CXCL10. CCL5. CCL2. 12000. 2250. 12000. 150. 500. 5000. 15000. 35000. 2000. 10000. 10000. 120. 1750. 30000. 12500. 400. 4000. 8000. 1500. 8000. 25000.

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Supplementary Figure 2

Supplementary Figure 2. MDA-MB-231. MDA-MB-231 HM.

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Supplementary Figure 2

Supplementary Figure 2. Week 1. Week 2. Indicator Cells GFP MFI.

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Supplementary Figure 2

A. HEK293. MRC-5. SKOV-3. MDAH-2774. Igfbp5 mRNA. Gapdh mRNA. anti-IGFBP-5. anti- b -actin. B. mock. IGFBP-5. mock. IGFBP-5. 2000. 1500. anti-CD31 (PECAM-1). tumor volume (mm 2 ). 1000. *. 500. 0. mock. IGFBP-5. 20. 15. number of blood vessels per tumor section. 10.

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Supplementary Figure 2

A. *. B. *. *. *. Supplementary Figure 2.

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Supplementary Figure 2

(a). (c). (b). (d). Supplementary Figure 2.

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Supplementary Figure 2

Supplementary Figure 2. Con. A. PELP1 Tg. Cyclin D1. B. Con. PELP1 Tg. Ser991 PELP1. Figure S2. Representative IHC images showing the status of cyclin D1 ( A ) and phos-PELP1 ( B )in the mammary glands of 6-month-old control and MMTV-rtTA-TetO-PELP1 bitransgenic mice.

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Supplementary Figure 2

HCT116. HCT116. NT. SN. NT. SN38. 5. 1.6. LC3 labelling. 4. 1.2. SN38 IC50 (nM). 3. 0.8. LC3 spots/cell. LC3. 0.4. 2. HCT116. Actin. 0. 1. Clonogenic assay. SN38. siCT. siATG5. siATG7. 0. shLUC. shMAPK14. HCT116. NT. SN38. 3. LC3. Cytotoxic assay. 100. GAPDH.

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Supplementary figure 2.

Supplementary figure 2. p = 0.018, Kolmogorov-Smirnov test p = 0.011, Chi squared test, Pearsons corrected.

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Supplementary Figure 2

Supplementary Figure 2.

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