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Understanding Response Inhibition in Adults with DCD: An ERP Investigation

This study investigates response inhibition in adults with Developmental Coordination Disorder (DCD) using an ERP paradigm. Results show differences in inhibitory errors and neurophysiological correlates between DCD and typical adults.

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Understanding Response Inhibition in Adults with DCD: An ERP Investigation

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  1. An ERP investigation of response inhibition in adults with DCDElisabeth HillDuncan BrownJosé van Velzen

  2. Background • Response inhibition - crucial for goal-directed behaviour in changing environment • Frontoparietal network implicated (behavioural / ERP) • Mixed findings in children with DCD (e.g. Wilson et al., 1997; Mandich et al. 2002, 2003; Querne et al. 2009) • Adults?

  3. Aims • Enhance understanding of response inhibition in DCD (Go/NoGo task) • Identify neurological mechanisms involved (with benefits for theory and intervention?) • Provide behavioural and neurophysiological evidence for continuation of coordination difficulty in adults with DCD

  4. Participants Movement battery: p<.001

  5. Infra-red starting position Possible probeLED Target button MIDLINE CROSSING STRAIGHT Experimental set-up Go/NoGo (delayed response) paradigm

  6. Experimental set-up 1000 msec between trials

  7. 900msec Hand cue: 200 msec 1000 msec between trials

  8. 900msec Hand cue: 200 msec 1000 msec between trials

  9. Probe flashed: 100 msec 900msec Hand cue: 200 msec 1000 msec between trials

  10. ** GO STOP 200msec Probe flashed: 100 msec 900msec Hand cue: 200 msec 1000 msec between trials

  11. ** P300 250-450 msec post STOP N200 150-350 msec post STOP Response initiated or withheld GO STOP 200msec Probe flashed: 100 msec 900msec Hand cue: 200 msec 1000 msec between trials

  12. Dependent variables • Compare: • Group (DCD vs. typical) • Movement type (straight vs. midline) • Behavioural results: • Inhibitory errors (fail to STOP) • ERPs: • N200; P300

  13. ERP predictions • N200 / P300: • increased in midline vs. straight movement (typicals) • decreased and delayed in DCD (vs. typical)

  14. Behavioural results group p<.001; movement p .001 group x condition p<.05

  15. N200 (150-350 msec post STOP) Frontal regions group .005; movement ns group x movement ns

  16. P300 (250-450 msec post STOP, shown 300-600 msec) Central regions group ns; movement ns group x movement ns

  17. Summary • More inhibitory errors in DCD vs. typical group • N200: • Greater enhancement in typical vs. DCD group • P300: • No differences between groups

  18. Implications • Inhibition (Go/No go) difficulties in adults with DCD • Biological underpinning (electrophysiological correlates) • Possible involvement of anterior cingulate cortex (ACC), prefrontal cortex (PFC) cf. N200? • Lifespan development

  19. EEG acquisition • EEG was recorded continuously with Ag/AgCl electrodes via 64 channel Biosemi system with linked earlobe reference. • Signals were amplified with a bandpass width of 0.1-100Hz and sampling rate was set at 512 Hz. • Data segments were epoched to 100 ms prior to onset of probe onset and 500 ms after probe onset for each movement condition. • Individual trials containing eye movement artifacts and errors were rejected before the averaging process. • Early visual-spatial potential N1(amplitude) was isolated (defined as negative going peak 100-300 ms post probe onset) and used for comparison of sensory gating of attended locations within visual perception

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