1 / 12

Neuromuscular junction

Neuromuscular junction. By Amar Kahlon. What is Neuromuscular J unction?.

shiri
Download Presentation

Neuromuscular junction

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Neuromuscular junction By Amar Kahlon

  2. What is Neuromuscular Junction? • It is junction of the axon terminal of a motor neuron with the motor end plate, the highly-excitable region of muscle fibres plasma membrane responsible for initiation of action potentials across the muscle's surface, ultimately causing the muscle to contract.

  3. Anatomy • Synatic knobs - ending of a nerve • Synaticcleft - a gap filled with extracellular fluid • Motor end plate - muscle membrane • Palisades - Muscle membrane thrown into folds

  4. Myasthenia Gravis Disease • which literally means "serious muscle-weakness is a neuromuscular disease leading to fluctuating muscle weakness and fatigue. It is an autoimmune disorder, in which weakness is caused by circulating antibodies that block acetylcholine receptors.

  5. Lambert-Eaton myasthenic syndrome • is a rare autoimmune disorder which affects voltage-gated calcium channels on the pre-synaptic membrane. The inhibition of the voltage-gated calcium channels prevents acetylcholine from being released from the presyntaptic terminal and the subsequent stimulation of the post-synaptic terminal which would lead to muscle contraction. • While children and young adults may be affected, the disease is usually observed in middle aged and older individuals. The incidence of the disease is difficult to determine due to its low frequency.

  6. THE END

More Related