Neuromuscular Junction and Infectious Disorders. Dayna Ryan, PT, DPT Winter 2012. Neuromuscular Junction Diseases. Botulism Myasthenia Gravis Lambert-Eaton Syndrome. Latin: “botulus,” meaning sausage Etiology Neurotoxin produced by Clostridium Botulinum Anaerobic, Gram-positive rods
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Dayna Ryan, PT, DPT
Fluctuating weakness & fatigability
Abnormal Thymus function in 75% of cases
Classifications of MG
Ocular myasthenia (~10-15%)
Generalized weakness (~85%)
Myasthenic crisis: respiratory failure
Antibodies block & damage ACh receptors
West Nile Virus
= meninges of the brain and SC become inflamed
Lyme disease was first reported in the US in the town of Old Lyme, Connecticut, in 1975.
Most cases (90%) in mid-Atlantic, northeast, & north central regions.
Incidence on the rise
23,763 cases in 2002
Swollen knee from chronic rheumatoid arthritis is most commonly recognized symptom
**15% of those who received early treatments still get complications involving heart, joints, and nervous system
MOST people have complete recovery within weeks or months of antibiotic treatment
It was first discovered in the United States in the summer of 1999 in New York. Since then, the virus has spread throughout the United States
Lesion: CNS, PNS, Multi-systems
(depends on where bitten)
2009 West Nile Virus Activity in US
(Reported to CDC as of December 2009)