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Dynamic interactive nanosystems and nanoreservoirs

Dynamic interactive nanosystems and nanoreservoirs. Phillip Hayes. Presentation aims. My background Academic & personal Previous chemistry project work (Quick overview ) Outline aims and research directions for dynano Initial lines of enquiry

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Dynamic interactive nanosystems and nanoreservoirs

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  1. Dynamic interactive nanosystems and nanoreservoirs Phillip Hayes

  2. Presentationaims • My background • Academic & personal • Previouschemistryprojectwork (Quick overview) • Outlineaims and research directions for dynano • Initial lines of enquiry • Guanidiniumbased phosphate recognition platforms. • G Quadruplex ligands and support structures • Possible applications / direction of work • Generateideas and research direction

  3. Introduction

  4. Previouswork Leftschool – worked in insurance Cricket in Australia Undergraduatestudiesat Manchester MetropolitanUniversity

  5. Introduction

  6. Halichlorine • Undergraduate project – organic synthesis • Marine sponge alkaloid • Harvested in minute quantities • Desirable target for synthesis

  7. Biological significance Inflammatory response VCAM-1 Metastatic processes Atherosclerosis Hepatitis C

  8. Syntheticaims Library of derviative compounds Retainbiologicalactivity Ease of synthesis

  9. Dynamic interactive nanosystems and nanoreservoirs Objectives • Synthesiselibraries of compounds that have potential DNA / G Quadruplex bindingcapabilities • Developfunctionalnanomaterials capable of DNA recognition properties, usingConstitutionalDynamicChemistry. • Developnanoreservoirsystems capable of smallmoleculebinding for QCM signal amplification

  10. Line of inquiry 1 – Phosphate recognition

  11. Guanidinium recognition

  12. DNA / G Quadruplex recognition • Shape dependentupon how G quartets stack. • Loop structure varies – parallel or anti-parallel looping

  13. G Quadruplex Ligands • Ligands bindstrongly to stabilise the G Quadruplex structure • Show preferentialaffinity for certain quadruplex loop structures • Createlibraries of moleculescontainingfunctionalitiessimilar to moleculesshown. • Ligand withmost stable affinity – express itself.

  14. G Quadruplex – potentialmembers of library

  15. DNA / G Quartet recognition – support structure

  16. Possible applications

  17. ~ QCM signal amplification _ DNA recognition platforms

  18. Presentationaims • My background • Academic & personal • Previouschemistryprojectwork • Outlineaims and research directions for dynano • Initial lines of enquiry • Guanidiniumbased phosphate recognition platforms. • G Quadruplex ligands and support structures • Possible applications / direction of work • Generateideas and research direction

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