George Beadle and Edward Tatum. “One ought to be able to discover what genes do by making them defective”. What do genes do?. What do genes do?. Their Model Organism:. Neurospora crassa. One Gene–One Enzyme Hypothesis. Neurospora crassa. One Gene–One Enzyme Hypothesis.
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Adrian Srb and Norman Horowitz (1944)
One Gene–One Protein
One Gene–One Polypeptide
3’ A C G T T G G A C 5’
5’ U G C A A C C U G 3’
5’ C G C A A C C U G 3’
= 20 amino
George Gamow’s Hypothesis
Analyzed the reading frame by making additions / deletions:
Normal: “The fat cat ate the rat”
1 deletion: “The atcatatet her at”
2 deletions: “The tca tat eth era t”
3 deletions: “fat cat ate the rat”
Francis Crick and Sydney Brennar
Who Murdered T.M.R.?
Use decoder on page _____