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This study categorizes the regulation of LTβR signaling in wild-type and relA-/- or relB-/- cells, highlighting the distinct roles of RelA and RelB. Results show their requirement for mediating LTβR signaling, with differences in regulation patterns among cell types.
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A wild-type Σ: 528 Category I Regulated only in wt cells Category II Regulated in wt and relA-/-cells relA-/- 30 30 366 Category III Regulated in wt and relB-/-cells Category IV Regulated in wt, relA-/-,and relB-/-cells 102 relB-/- B Cat I/1 Cat I/2 Both RelA and RelB are required for mediating LTβR signaling (- regulation) n=205 Both RelA and RelB are required for mediating LTβR signaling (+ regulation) n=161 Cat II/1 Cat II/2 Cat II/3 Cat II/4 RelB mediates LTβR signaling (+ regulation) n=13 RelB mediates LTβR signaling (- regulation) n=17 n=0 n=0 Cat III/1 Cat III/2 Cat III/3 Cat III/4 RelA mediates LTβR signaling (+ regulation) n=54 RelA mediates LTβR signaling (- regulation) n=43 n=3 n=2 Cat IV/3 Cat IV/4 Cat IV/5 Cat IV/1 Cat IV/2 n=0 n=0 n=0 RelA and RelB redundantly mediate LTβR signaling (- regulation) n=10 RelA and RelB redundantly mediate LTβR signaling (+ regulation) n=20 n=0 n=0 n=0 Cat IV/6 Cat IV/7 Cat IV/8
