Just enough biochemistry to be dangerous??. http://www.detoxi-pad.com/. Just enough biochemistry to be dangerous??. http://www.tahitiannoni.com/united_states/english/retail/store/research/index.html. Chapter 15. Design of metabolism. http://www.chem.uwec.edu/Chem454_S08/MetabolicchartBig.pdf.
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Design of metabolism
For biochemical reactions, we define a different standard state for the concentration of H+
BUT,it’s kinetically stable
Free energies are additive; favorable rxns can drive unfavorable;e.g.sequential coupling
Example:Glucose to glucose-6-phosphate
Example: calculate G°’ for this reaction involving phosphoenolpyruvate (PEP) and decide whether or not it is spontaneous
Under aerobic conditions, glucose is oxidized to carbon dioxide and water
e.g. Substrate Cycling:
See glycolysis (F-6-P to F1,6-BP)