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Just enough biochemistry to be dangerous??. http://www.detoxi-pad.com/. Just enough biochemistry to be dangerous??. http://www.tahitiannoni.com/united_states/english/retail/store/research/index.html. Chapter 15. Design of metabolism. http://www.chem.uwec.edu/Chem454_S08/MetabolicchartBig.pdf.

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just enough biochemistry to be dangerous2
Just enough biochemistry to be dangerous??

http://www.tahitiannoni.com/united_states/english/retail/store/research/index.html

chapter 15

Chapter 15

Design of metabolism

slide6

For biochemical reactions, we define a different standard state for the concentration of H+

  • standard state for [H+] = 10-7 M, pH = 7.0
  • this modified standard state is given the symbol G°’
slide7
ATP
  • the experimental value of K’eq = 2.23 x 105
atp why
ATP-Why?

repulsion

resonance

BUT,it’s kinetically stable

slide10
"High energy" substance: a thermodynamically unstable substance whose hydrolysis or decomposition can be easily coupled to an unfavorable reaction. The arbitrary cut-off is~-10kJ/mol. There is no such thing as a "high energy bond" per se.
coupled reactions
Coupled Reactions

Free energies are additive; favorable rxns can drive unfavorable;e.g.sequential coupling

slide13

Simultaneous coupling

Example:Glucose to glucose-6-phosphate

slide14

Example: calculate G°’ for this reaction involving phosphoenolpyruvate (PEP) and decide whether or not it is spontaneous

      • use the following information from Table 14.1
slide15

Under aerobic conditions, glucose is oxidized to carbon dioxide and water

      • the efficiency of the energy conservation under aerobic conditions is approximately 34%
  • Metabolism concerns how you get from here to there!!
factors affecting metabolic rate
Factors Affecting Metabolic Rate
  • Metabolism operates at a steady state.
  • Metabolites flow through the steady state
factors affecting metabolic rate29
Factors Affecting Metabolic Rate
  • Metabolites flow through the steady state

ATP

factors affecting metabolic flow or flux through pathways
Factors Affecting Metabolic Flow or flux through pathways
  • Amounts of enzymes
  • Catalytic activity of enzymes
  • Availability of substrates
control of metabolic flux j

J

J

S

A

B

CONTROL OF METABOLIC FLUX, J

rate determining

step

P

e.g. glucose

pyruvate

control of metabolic flux j36
CONTROL OF METABOLIC FLUX, J

e.g. Substrate Cycling:

See glycolysis (F-6-P to F1,6-BP)