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Performance-Enhancing Substances. 11.1. Performance can be enhanced by the use of nutritional supplements, pharmacological aids and physiological aids. Nutritional supplements include vitamins, mineral, protein/amino acid supplements, creatine, caffeine etc.
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Performance can be enhanced by the use of nutritional supplements, pharmacological aids and physiological aids. • Nutritional supplements include vitamins, mineral, protein/amino acid supplements, creatine, caffeine etc. • Pharmacological aids include pain-killers, steroids, prohormones & certain hormones and erythropoietin. • Physiological aids include blood doping and drug masking.
Vitamins and Minerals • Not well regulated and may commonly have no effect on performance beyond placebo. • In general, a healthy diet will supply all the vitamin and minerals a person needs. Moreover, vitamin and mineral supplements are typically in doses much higher (~1000x) than those recommended and may cause harm. • Certain amino acids may lead to increased muscle development; however, as discussed previously, an excess of amino acids or proteins can lead to increased urea and ammonia production and kidney damage.
Protein and amino acid supplements • Carnitine is marketed as a fat burner • improves anaerobic respiration (escorts long chain fatty acids to the mitochondria for use in the Kreb’s cycle) • Creatine is marketed as an aid to muscle development. • In small quantities its ingestion may aid in performance for short, high energy activities that rely on the ATP-PC chain; • large quantities are excreted. • Adverse side effects are not well documented, • Linked to body odour and testicular shrinkage.
Caffeine • well known performance aid found naturally in coffee, tea and chocolate. • In low to moderate doses, caffeine will increase blood pressure, alertness and decrease fatigue. • Routine ingestion will raise the body’s tolerance to its effects (body will actually depress blood pressure before routine caffeine consumption) leading to the perception of addiction.
Parmocological Aids • “doping” • Pain-masking drugs • Anabolic steroids • Prohormones • Human growth hormone (hGH) • erythropoietin
Pain-masking drugs • Many pharmacological aids are banned by major sporting bodies as they may give athletes an unfair advantage. • Pain-killers called narcotic analgesics can mask the pain of injuries by blocking the body’s pain receptors. • Include morphine & heroine. • Habit-forming and can lead to more injuries when the normal signals of damage are ignored.
Anabolic steroids • Based on testosterone (mimic) • Used by athletes to increase muscle mass and quicker recovery • Side effects include liver damage, aggression, breasts in males and the masculinisation of females.
Prohormones • Androgenic steroids (Androstenedione) • Mark McGwire broke the homerun record while using “Andro” in 1998 • Can become or simulate testosterone or androgen. • Marketed as being similar to that of anabolic steroids, while side effects include acne, baldness, feminization of males and aggression.
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Human growth hormone (hGH) • Believed to aid in increasing muscle mass and bone strength while maintaining body mass • Can lead to heart problems, excessive growth of the extremities and organs. • More difficult to detect than steroids due to natural levels in body
Erythropoietin (EPO) • “Blood doping” replaced real blood doping • Used to increase haemoglobin levels and therefore the blood’s ability to carry and deliver oxygen. • Useful for endurance athletes, especially since it is very difficult to detect. • Can lead to blood clots and cyclists have died from using EPO • Other restricted pharmacological substances include alcohol, marijuana, local anaesthetics, corticosteroids and beta blockers.
Physiological aids • fall into two classes: blood doping and drug masking. • Blood doping involves the removal and storage of blood 6-8 weeks pre-competition, then reintroducing it within the week before competition. EPO has replaced this practice • Drug masking is the use of legal drugs or substances to mask illicit or restricted substances. • include diuretics, which increase the volume and frequency of urination in order to decrease the concentration of drugs detected in urine testing.