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Muscle Function and Metabolism

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Muscle Function and Metabolism

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  1. Muscle Function and Metabolism

  2. Adenosine Triphosphate (ATP) • ATP is the source of energy for muscle contraction. • Muscles store a very limited amount of ATP (4-6 sec. worth at most). • ATP must be regenerated if contraction is to continue • ATP can be generated by one of three pathways….

  3. Aerobic Metabolism/Cellular Respiration • Description: • Occurs in mitochondria, requires oxygen, and involves a complex sequence of chemical reactions. 2. Chemical Formula: Glucose + oxygen carbon dioxide + water+ energy (36 ATP) 3. When this system is used: • Used during prolonged, endurance activities which maintain a constant heart rate • As long as there is enough oxygen available relative to ATP demand, a muscle will utilize aerobic metabolism. • Posture, most daily movements, marathon runs, bike riding

  4. Anaerobic Metabolism/Glycolysis • Description: • When muscles contract vigorously, the bulging muscles compress blood vessels within, impairing oxygen delivery. • This pathway can occur in the absence of oxygen. 2. Chemical Formula: Glucose  lactic acid +energy (2 ATP) 3. When this system is used: • When large amounts of ATP relative to available O2are needed. Usually for exercise about 30-40 seconds long. • Tennis, soccer, 100 meter swim

  5. Anaerobic Metabolism/Creatine Pathway • Description: • Utilizes the molecule creatine phosphate to regenerate ATP, after stored ATP is depleted. 2. Chemical Formula: Creatinephosphate + ADP Creatine+ ATP (1 ATP) 3. When this system is used: • Moblized at the beginning of exercise, before other pathways ‘kick in’. • Creates enough energy for about 15 seconds of contraction. • 100 meter dash, weightlifting

  6. Summary of Muscle Metabolism

  7. Fast Twitch vs. Slow Twitch MusclesSprinter vs. Marthoner

  8. Slow Twitch/Fast Twitch Analogy: birds White meat-fast twitch, found in breast and wings, used for flying-quick movements. Dark meat-slow twitch, found in legs, used for walking.

  9. Muscle Fatigue Definition: the state of physiological inability to contract Causes: 1. Occurs when ATP production fails to keep up with ATP use. • Deficiency of ATP, as opposed to total absence of ATP which leads to a continuous state of contraction (rigor mortis, writers cramp) 2. Accumulation of lactic acid and ionic imbalances also contribute. • decreases muscle pH • causes burning sensation • interferes with actin/myosin binding

  10. Muscle conditions • Muscle cramps- (charley horse)sudden involuntary contraction of muscles due to injury, deficiency in calcium or phosphate, lack of blood flow, nerve tissue damage or dehydration. • Muscle twitches -often cause by a single nerve, due to fatigue, lack of water, stress and anxiety. • ALS-Lou Gehrig’s disease-damages motor neurons, leads to loss of movement. • Muscular dystrophy-skeletal muscle progressively weaken.