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Evolution of Active-Site Chemistry in ROXs and JmjC-Containing Oxygenases

This study proposes a sequence of evolutionary changes in the active-site chemistry of ROXs and related JmjC-containing 2OG-dependent oxygenases. By analyzing their structural and functional variations, the research elucidates how these enzymes have adapted to different biological roles. The findings contribute to our understanding of enzyme evolution and highlight potential avenues for biotechnological applications. This work builds upon existing knowledge and provides insights into the intricate relationship between enzyme structure and function.

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Evolution of Active-Site Chemistry in ROXs and JmjC-Containing Oxygenases

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  1. Proposed sequence of evolution of active-site chemistry of ROXs and related JmjC-containing 2OG-dependent oxygenases. R Chowdhury et al. Nature 000, 1-5 (2014) doi:10.1038/nature13263

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