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Improvement in Outcomes of Clinical Islet Transplantation: 1999–2010

Featured Article :. Improvement in Outcomes of Clinical Islet Transplantation: 1999–2010.

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Improvement in Outcomes of Clinical Islet Transplantation: 1999–2010

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  1. Featured Article: Improvement in Outcomes of Clinical Islet Transplantation: 1999–2010 Franca B. Barton, M.S., Michael R. Rickels, M.D., Rodolfo Alejandro, M.D., Bernhard J. Hering, M.D., Stephen Wease, M.P.H., Bashoo Naziruddin, Ph.D., Jose Oberholzer, M.D., Jon S. Odorico, M.D., Marc R. Garfinkel, M.D., Marlon Levy, M.D., Francois Pattou, M.D., Ph.D., Thierry Berney, M.D., Antonio Secchi, M.D., Shari Messinger, Ph.D., Peter A. Senior, Ph.D., M.R.C.P., Paola Maffi, M.D., Ph.D., Andrew Posselt, M.D., Ph.D., Peter G. Stock, M.D., Ph.D., Dixon B. Kaufman, M.D., Ph.D., Xunrong Luo, M.D., Ph.D., Fouad Kandeel, M.D., Ph.D., Enrico Cagliero, M.D., Nicole A. Turgeon, M.D., Piotr Witkowski, M.D., Ph.D., Ali Naji, M.D., Ph.D., Philip J. O’Connell, M.D., Ph.D., Carla Greenbaum, M.D., Yogish C. Kudva, M.D., Kenneth L. Brayman, M.D., Ph.D., Meredith J. Aull, Pharm.D., Christian Larsen, M.D., Ph.D., Tom W.H. Kay, M.D., Ph.D., Luis A. Fernandez, M.D., Marie-Christine Vantyghem, M.D., Ph.D., Melena Bellin, M.D., A.M. James Shapiro, M.D., Ph.D. Diabetes Care Volume 35: 1436-1445 July, 2012

  2. Study Objectives • To describe trends of primary efficacy and safety outcomes of islet transplantation in type 1 diabetes recipients with severe hypoglycemia from the Collaborative Islet Transplant Registry (CITR) from 1999 to 2010 Barton F. B. et al. Diabetes Care 2012;35:1436-1445

  3. Study Design & Methods • 677 islet transplant-alone or islet-after-kidney recipients with type 1 diabetes in the CITR analyzed for five primary efficacy outcomes and overall safety to identify any differences by early (1999–2002), mid (2003–2006), or recent (2007–2010) transplant era based on annual follow-up to 5 years. Barton F. B. et al. Diabetes Care 2012;35:1436-1445

  4. Barton F. B. et al. Diabetes Care 2012;35:1436-1445

  5. Barton F. B. et al. Diabetes Care 2012;35:1436-1445

  6. Barton F. B. et al. Diabetes Care 2012;35:1436-1445

  7. Barton F. B. et al. Diabetes Care 2012;35:1436-1445

  8. Barton F. B. et al. Diabetes Care 2012;35:1436-1445

  9. Barton F. B. et al. Diabetes Care 2012;35:1436-1445

  10. Barton F. B. et al. Diabetes Care 2012;35:1436-1445

  11. Barton F. B. et al. Diabetes Care 2012;35:1436-1445

  12. Barton F. B. et al. Diabetes Care 2012;35:1436-1445

  13. Barton F. B. et al. Diabetes Care 2012;35:1436-1445

  14. Conclusions • The CITR shows improvement in primary efficacy and safety outcomes of islet transplantation in recipients who received transplants in 2007–2010 compared with those in 1999–2006, with fewer islet infusions and adverse events per recipient Barton F. B. et al. Diabetes Care 2012;35:1436-1445

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