Hypothalamus. Historical Perspective. Wilhelm His (1893) Distinct division of diencephalon Harvey Cushing (1920s), neurosurgeon Diabetes insipidus: excess water excretion & thirst Cushing syndrome: excess secretion of cortisol 1930s: cytoarchitectural definition of nuclei
Adrenal cortex secretes too much cortisol.
Results from tumor in pituitary or adrenal cortex.
Cortisol causes proteins to break down.
Muscle atrophy, skin thinner, bones stop growing & easily fractured, lymphatic tissue shrinks -reduced resistance to infection, fat redistributed from arm & legs to face & trunk