Hypothalamus. Historical Perspective. Wilhelm His (1893) Distinct division of diencephalon Harvey Cushing (1920s), neurosurgeon Diabetes insipidus: excess water excretion & thirst Cushing syndrome: excess secretion of cortisol 1930s: cytoarchitectural definition of nuclei
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Adrenal cortex secretes too much cortisol.
Results from tumor in pituitary or adrenal cortex.
Cortisol causes proteins to break down.
Muscle atrophy, skin thinner, bones stop growing & easily fractured, lymphatic tissue shrinks -reduced resistance to infection, fat redistributed from arm & legs to face & trunk