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Familial Factors in Longevity: Exploring Complex Environmental and Genetic Effects

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  1. Familial Factors in Longevity: Exploring Complex Environmental and Genetic Effects Leonid A. Gavrilov, Ph.D. Natalia S. Gavrilova, Ph.D. Center on Aging NORC and The University of Chicago Chicago, USA

  2. Numerous studies showed that biological relatives of centenarians have substantial survival advantage compared to biological relatives of shorter-lived individuals.

  3. Relatives of 1,711 centenarians born in 1880-1895 Who lives longer in centenarian families?Siblings > Spouses > Siblings-in-law *Mean lifespan conditional on survival to age 50

  4. Little is known about effects of centenarian’s sex on longevity of relatives In this study effects of centenarian’s sex were used to explore genetic and environmental effects on longevity

  5. Dataset We have developed and analyzed a new computerized database on 1,711 validated centenarians born in 1880-1895 in the the United States, their parents and 13,185 shorter-lived siblings.

  6. Methods Gompertz multivariate regression models were used to model survival time between age 50 and death for centenarian siblings. Models for brothers and sisters were analyzed separately. Student t-test was used to compare mean life spans.

  7. Computerized genealogies is a promising source of information about potential predictors of exceptional longevity: life-course events, early-life conditions and family history of longevity

  8. Steps of the study 23,127 records of centenarians born in 1880-1895 with known information about parents were identified using the Rootsweb genealogical website 2,834 centenarians having detailed information on their 21,893 siblings were selected 1,711 centenarians with their death dates verified using the Social Security Death Index were used for further analyses Finally data on 398 male and 1,313 female centenarians, their 13,419 siblings, 1,307 spouses, and 7,924 siblings in law were used in the study

  9. Having centenarian brother is ‘better’ than centenarian sister (for males only) Life expectancy of siblings at age 50 depending on the sex of centenarian

  10. Survival of male siblings of centenarians, by sex of centenarian

  11. Having centenarian son is ‘better’ than centenarian daughter (for fathers only) Life expectancy of parents at age 50 depending on the sex of centenarian

  12. Male sex of centenarian is ‘better’ for brother’s longevityGomperz hazard regression model for survival of brothers of centenarians after age 50. N=5,287

  13. Sex of centenarian is not important for sister’s longevityGomperz hazard regression model for survival of sisters of centenarians after age 50. N=4,849

  14. Sex-specific Survival Threshold (SSST) Hypothesis Because of male and female centenarians have different survival threshold to reach age 100, sex-specific effects are observed

  15. Test of the SSST hypothesisCompare siblings of male centenarians to siblings of females survived to age 103 Probability of survival to 103 for females is similar to probability of reaching age 100 for males (according to the 1900 U.S. cohort)

  16. It is ‘better’ to have the same sex as your centenarian-sibling Life expectancy of siblings at age 50 depending on the sex of centenarian

  17. SSST Hypothesis is confirmedfor brothers of centenariansGomperz hazard regression model for survival of male centenarianbrothers and brothers of females lived 103+ years after age 50. N=2,243

  18. SSST Hypothesis is NOT confirmed for sisters of centenarians: sex is still importantGomperz hazard regression model for survival of male centenariansisters and sisters of females lived 103+ years after age 50. N=2,022

  19. Using siblings-in-law as a control group Siblings-in-law do not share genetic background and living conditions with centenarians On the other hand, they usually come from a similar socio-economic background, so may be a good control group

  20. Sex of centenarian is important for siblings but not for siblings-in-law Life expectancy of relatives at age 50 depending on the sex of centenarian

  21. Only women benefit from having centenarian spouse Life expectancy of spouses at age 50 depending on the sex of centenarian

  22. For sisters of centenarians father’s longevity becomes unimportantGomperz hazard regression model for survival of centenariansisters after age 50. N=3,141

  23. For brothers of centenarians father’s longevity is still importantGomperz hazard regression model for survival of centenarian married brothers after age 50. N=3,141

  24. Conclusion Familial factors in human longevity are likely to be sex-specific. Exploring complex environmental and genetic effects in longevity could be facilitated by further analysis of sex-specific effects

  25. Acknowledgments This study was made possible thanks to: generous support from the National Institute on Aging grant #R01AG028620

  26. For More Information and Updates Please Visit Our Scientific and Educational Website on Human Longevity: • http://longevity-science.org And Please Post Your Comments at our Scientific Discussion Blog: • http://longevity-science.blogspot.com/

  27. Exceptional longevity in a family of Iowa farmers • Father: Mike Ackerman, Farmer, 1865-1939 lived 74 years • Mother: Mary Hassebroek 1870-1961 lived 91 years • Engelke "Edward" M. Ackerman b: 28 APR 1892 in Iowa 101 • Fred Ackerman b: 19 JUL 1893 in Iowa 103 • Harmina "Minnie" Ackerman b: 18 SEP 1895 in Iowa 100 • Lena Ackerman b: 21 APR 1897 in Iowa 105 • Peter M. Ackerman b: 26 MAY 1899 in Iowa 86 • Martha Ackerman b: 27 APR 1901 in IA 95 • Grace Ackerman b: 2 OCT 1904 in IA 104 • Anna Ackerman b: 29 JAN 1907 in IA 101 • Mitchell Johannes Ackerman b: 25 FEB 1909 in IA 85