do now
Download
Skip this Video
Download Presentation
Do Now

Loading in 2 Seconds...

play fullscreen
1 / 17

Do Now - PowerPoint PPT Presentation


  • 75 Views
  • Uploaded on

Unit 5 Part 1: Is cancer in our genes?. Do Now.

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'Do Now' - moshe


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
do now
Unit 5 Part 1: Is cancer in our genes?Do Now

The function of the BRCA1 protein is to prevent our cells from becoming cancerous. If a cell is dividing too much, the BRCA1 protein can repair the cell so that it undergoes mitosis normally. A portion of the BRCA1 gene (the DNA with instructions on how to make the BRCA1 protein) is shown below.

  • TAC TGA GTT ACA CGA
  • Write out the sequence of mRNA that would be produced during transcription of the BRCA1 gene.
slide2
Use the genetic code chart to determine the amino acids that make up this portion of the BRCA1 protein.

What would happen if a person’s BRCA1 protein was not functional?

what is this diagram saying
What is this diagram saying?

Nucleotide Sequence

Amino Acid Sequence

Protein Shape

Protein Function

what is this diagram saying1
What is this diagram saying?

Nucleotide Sequence

Amino Acid Sequence

Protein Shape

Protein Function

HIS

LEU

VAL

GLY

slide6
FACT:Many people with breast cancer have BRCA1 proteins that are the wrong shape or missing amino acids.

How does this happen?

Mutations!

slide8
Identify the Mutation

GTTACGAA

GTTACTGAA

GTTATGAA

GTACGAA

Mutation A: ___________________________

Mutation B: ____________________________

Mutation C: ____________________________

slide9
Stop and Jot

Based on what you have learned thus far, create your own definition of what a “mutation” is

slide10
Word of the Day

Mutation- a random change in the sequence of bases.

slide11
Discussion Question

Insertions and deletions are often called “frameshift mutations” and are far more dangerous than substitution mutations. Why would an insertion or deletion be worse than a substitution?

slide12
Cancer Connection

Compare the beginning sequence of Theresa’s BRCA1 gene to the normal sequence below.

Theresa’s BRCA1 gene: TACTGAGTTACTACGA

Normal BRCA1 gene: TACTGAGTTACACGA

slide13
Cancer Connection

How would her mRNA codons be different than a normal person’s?

How would her amino acid sequence be different than a normal person’s?

slide14
Cancer Connection

State how the BRCA1 protein function would be altered as a result of this mutation.

slide15
Cancer Connection

Synthesize all of the information that you learned today to describe why so many people in Theresa’s family have breast cancer.

slide16
Cancer Connection

Sample data from a patient is shown below. Fill in the patient’s missing codon.

slide17
Cancer Connection

The patient’s BRCA1 protein is normal despite the fact that the BRCA1 gene has a mutation. Explain how this is possible in terms of the genetic code.

ad