1 / 11

Catabolism s of triacylglycerols and phospholipids .

Catabolism s of triacylglycerols and phospholipids. Synthesis of Triacylglycerols (TGs) and Glycerophospholipids (GPLs). Glycerol 3-phosphate can be obtained either by the reduction of dihydroxyecetone phosphate (primarily) or by the phosphorylation of glycerol (to a lesser extent).

miya
Download Presentation

Catabolism s of triacylglycerols and phospholipids .

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Catabolisms of triacylglycerols and phospholipids.

  2. Synthesis of Triacylglycerols (TGs) and Glycerophospholipids (GPLs) Glycerol 3-phosphate can be obtained either by the reduction ofdihydroxyecetone phosphate (primarily) or by the phosphorylation of glycerol (to a lesser extent).

  3. Formation of phosphatidate Two separate acyl transferases (AT) catalyze the acylation of glycerol 3-phosphate. The first AT (esterification at C1) has preference for saturated fatty acids; the second AT (esterification at C2) prefers unsaturated fatty acids.

  4. Phosphatidic acid(phosphatidate)is an common intermediate in the synthesis of TGs and GPLs Phosphatidate can be converted to two precursors: - diacylglycerol (precursor for TGs and neutral phospholipids) - cytidine diphosphodiacylglycerol(CDP-diacylglycerol) (precursor for acidic phospholipids)

  5. Synthesis of TGs and neutral phospholipids Phospha- tidyl- etha-nolamine Triacyl-glycerol Phosphatidylcholine

  6. Synthesis of TGs Diacylglycerol can be acylated to triacylglycerol (in adipose tissue and liver) Enzyme: acyltransferase

  7. Synthesis of neutral phospholipids CDP-choline or CDP-ethanolamine are formed from CTP by the reaction: CTP + choline phosphate  CDP-choline + PPi CTP + ethanolamine phosphate  CDP-ethanolamine + PPi Diacylglycerol react with CDP-choline or CDP-ethanolamine to form phosphatidylcholine or phosphatidylethanolamine

  8. Synthesis of acidic phospholipids

  9. Phosphatidylinositol can be converted to phosphatidylinositol 4,5-biphosphate which is the precursor of the second messenger inositol 1,4,5-triphosphate

  10. Interconver-sions of phosphati-dylethanol-amine and phospha-tidylserine

More Related