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(N=166,792) Center randomization

8 KPNC Centers Total Phase Patients: (N=188,781). Exclusions (N=21,989) Age<18 or >85 In SNF or hospice No drug benefit. (N=166,792) Center randomization. 4 Centers. 4 Centers. Lost to Follow- up in <6 mos N=1119 ( 6.3%) Disenrolled or dropped drug

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(N=166,792) Center randomization

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  1. 8 KPNC Centers Total Phase Patients: (N=188,781) Exclusions (N=21,989) Age<18 or >85 In SNF or hospice No drug benefit (N=166,792) Center randomization 4 Centers 4 Centers Lost to Follow- up in <6 mos N=1119 ( 6.3%) Disenrolled or dropped drug benefit: 711 Moved to non- study center 179 Death 229 Intervention Centers (N=95,355) Control Centers N=71,437 Lost to Follow- up in <6 mos N=1112 ( 7.7%) Disenrolled or Dropped drug benefit: 727 Moved to non- study center 219 Death 166 Met at least one eligibility criterion (n= 14,535, 20.3%) Met at least one eligibility criterion (N=17,703, 18.6%) N=16,584 N=13,423 Priority 1 SBP ≥ 140 3080 (3.2%) Priority 2 LDL-C ≥ 130 2431 (2.5%) Priority 3 A1c ≥ 9% 1318 (1.4%) Priority 1 SBP ≥ 140 2905 (4.1%) Priority 2 LDL-C ≥ 130 1789 (2.5%) Priority 3 A1c ≥ 9% 1059 (1.5%) Priority 4 SBP ≥ 130 3878 (4.1%) Priority 5 LDL-c ≥ 100 4876 (5.1%) Priority 6 A1c 7-8.9% 3750 (3.9%) Priority 6 A1c 7-8.9% 3007 (4.2%) Priority 4 SBP ≥ 130 3583 (5.0%) Priority 5 LDL-c ≥100 3526 (4.9%)

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