1 / 25

Understanding Tumor Biology and DNA Repair Mechanisms in Human Cells

This comprehensive overview explores critical aspects of tumor biology, including the roles of proto-oncogenes and tumor suppressor genes, illustrated through various figures. Key processes such as contact inhibition, mismatch repair mechanisms, base-excision repair, and nucleotide excision repair are discussed. The document also highlights important proteins like BRCA1 and P53 that are essential in maintaining genomic stability and regulating the cell cycle. Understanding these interactions provides insight into cancer development and potential therapeutic targets.

milt
Download Presentation

Understanding Tumor Biology and DNA Repair Mechanisms in Human Cells

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Figure 18.01 Tumors in human liver.

  2. Figure 18.02 Action of proto-oncogenes and tumor suppressor genes.

  3. Figure 18.03a Contact inhibition.

  4. Figure 18.03b Contact inhibition.

  5. Page 561a.

  6. Page 561b.

  7. Figure 18.04 the mismatch repair protein MutS bound to DNA.

  8. Figure 18.05 Base-excision repair.

  9. Figure 18.06a Glycosylase binding to oxoG.

  10. Figure 18.06b Glycosylase binding to oxoG.

  11. Figure 18.07a The uracil-DNA glycosylase reaction.

  12. Figure 18.07b The uracil-DNA glycosylase reaction.

  13. Figure 18.08 The AP endonuclease reaction.

  14. Figrue 18.09 Nucleotide excision repair.

  15. Figure 18.10 Xeroderma pigmentosum.

  16. Figure 18.11 Recombination to bypass a single-strand gap.

  17. Figure 18.12 Homolgous recombination to replicate past a double-strand break.

  18. Figure 18.13 End joining of broken DNA.

  19. Figure 18.14 Model of a RecA-DNA complex.

  20. Figure 18.15 The cell cycle and cyclin activity.

  21. Figure 18.16 Model of DNA damage response pathway.

  22. Figure 18.17 Action of the retinoblastoma protein.

  23. Figure 18.18 Partial structure of the BRCA1 protein.

  24. Figure 18.19a Structure of the core domain of P53.

  25. Figure 18.19b Structure of the core domain of P53.

More Related