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Life Course Socioeconomic Status, Social Context and Cardiovascular Disease: The LCSES Study Kathryn Rose, PhD for The LCSES Study Team. Background. LCSES and ARIC Studies.

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Life Course Socioeconomic Status, Social Context and Cardiovascular Disease: The LCSES StudyKathryn Rose, PhDfor TheLCSES Study Team
lcses and aric studies
LCSES and ARIC Studies
  • As part of the ARIC study, information on mid to later life socioeconomic status (SES) was collected at each of the four examinations
  • As an ancillary study, LCSES collected additional information from surviving participants about earlier life SES circumstances
    • Individual-level SES
    • Place of residence
slide4

LCSES Study Goals

  • Examine the association between SES across the life course and CVD-related outcomes
  • Determine the extent to which the current and historical (neighborhood) context modify the association of individual-level SES exposures and CVD events
  • Identify explanatory mechanisms for the SES-CVD association
lcses questionnaire
LCSES Questionnaire
  • Administered during 2001-02 ARIC annual telephone follow-up (AFU)
    • 44 questions about childhood and earlier adulthood social exposures
      • Individual-level SES
      • Military Service
      • Place of residence
        • Used to link participants with historical census data
lcses participants
LCSES Participants
  • N = 12,716
  • 80.5% of the baseline ARIC participants
  • Approximately 95% of cohort survivors
lcses participant characteristics
LCSES Participant Characteristics

RACE/GENDER

Black Women

Black Men

White Women

White Men

16.5%

9.0%

40.8%

33.8%

AGE at BASELINE

45-49

50-54

55-59

60-64

29.5%

27.3%

23.7%

19.7%

individual level childhood ses
Individual Level Childhood SES:
  • Mother and father’s (or other caretaker’s)
    • Education
    • Occupation
      • Census-based categories analogous to those used in ARIC study
      • Owner vs. worker
      • Whether or not managed or supervised
    • Home ownership
recalled individual level ses related attributes in earlier adulthood
Recalled Individual-level SES-Related Attributes in Earlier Adulthood
  • Occupation at ages 30, 40, and 50
    • Grouped into Bureau of Census Job Categories
  • Characteristics of Job
    • Owner vs. Worker
    • Managerial/Supervisory
  • Home ownership
type of historical data collected1

Type of Historical Data Collected

Contextual Level

(Place of Residence)

childhood place of residence
Childhood Place of Residence
  • City / County / State of Residence during childhood
    • Data cleaning / editing
    • 3% resided outside of the US
    • 44% resided in the same county as in midlife
  • Linking with county-level census data
    • Chose decennial census (1930, 1940, 1950) that corresponded most closely to where participant livedat 10 years of age
    • Of the 12,314 participants who lived in the US as children, 99% were linked to county-level census data
distribution of participants by birth cohort
Distribution of Participants by Birth Cohort

4000

3500

3000

2500

Number

2000

1500

1000

500

0

1921-25

1926-30

1931-35

1936-40

1941-45

ARIC Participant’s Birth Cohort

place of residence at ages 30 40 and 50
Place of Residence at Ages 30, 40, and 50
  • Participants asked to provide their complete street address
  • Goal: link with census tract data from historical census (1960 – 1980) most closely corresponding to the given age
  • Only queried about address for a given age if not already in ARIC at this age
progress to data
Progress to Data
  • Strategies for working with complex historical census data have been developed
  • Individual and contextual / neighborhood socio-economic exposure data across the life course has been assembled for study participants
  • Various research projects focusing on cardiovascular disease related outcomes are in progress