life cycle and antiviral effect. Major steps . Recognition Attachment Penetration Uncoating Early protein synthesis Nucleic acid synthesis Late protein synthesis Assembly Release. Attachment/Adsorption.
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An energy-dependent process, and the cell must be metabolically active for the penettration
1)Translocation of the entire virus particle across the plasma membrane.
2) Endocytosis of the virus into intracellular vesicles (endosomes).
3) Fusion of the virus envelope with a cellular membrane.
docosanol(HSV): by inhibiting the fusion of the human host cell with the viral envelope of the herpes virus, thus preventing its replication. This mechanism has neither been directly observed nor proven, however.
IFN-α is also made synthetically as medication.
foscarnet(CMV):Foscarnet is a structural mimic of the anion pyrophosphate that selectively inhibits the pyrophosphate binding site on viral DNA polymerases at concentrations that do not affect human DNA polymerases. Because foscarnet is not activated by viral kinases it maintains activity against viruses like HSV and VZV that have respectively developed mutant thymidinekinase and UL97 encoded protein kinase, to gain resistance to other DNA polymerase inhibtors, like acyclovir and ganciclovir. Therefore, foscarnet is often used in acyclovir- or ganciclovir-resistant disease.