life cycle and antiviral effect By uzair hashmi. Major steps . Recognition Attachment Penetration Uncoating Early protein synthesis Nucleic acid synthesis Late protein synthesis Assembly Release. Attachment/Adsorption.
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An energy-dependent process, and the cell must be metabolically active for the penettration
1)Translocation of the entire virus particle across the plasma membrane.
2) Endocytosis of the virus into intracellular vesicles (endosomes).
3) Fusion of the virus envelope with a cellular membrane.
The important strategies in the synthesis of various viral genome syntheses are :
IFN-α is also made synthetically as medication.
mechanism of Amantadine's antiviral activity involves interference with a viral protein, M2, required for the viral particle to become "uncoated" once taken inside a cell by endocytosis
inhibits influenza's viral replication, by preventing the uncoating of the virus's protective shells, the envelope and capsid.
PIs prevent viral replication by inhibiting the activity of proteases, e.g.HIV-1 protease, enzymes used by the viruses to cleave nascent proteins for final assembly of new virons.