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Lots of help from Cristian Botez, Ashfia Huq, Yuan-Hon Kiang, Silvina Pagola, many other people who don t care to be men

Why powders?Why synchrotron radiation?Examples:Real problem - distinguishing polymorphs with similar x-ray patternsReal problem determining small concentrations of a protected polymorphCrystal structure solutionsProxy for a real problem determining solid form of a small amount of API in

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Lots of help from Cristian Botez, Ashfia Huq, Yuan-Hon Kiang, Silvina Pagola, many other people who don t care to be men

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    43. Acknowledgements : Ashfia Huq, Silvina Pagola (now at Apotex) Dept. of Physics & Astronomy, SUNY Stony Brook, 11794-3800 Y.-H. Kiang, Wei Xu Pharmaceutical Research, Merck & Co., Inc. West Point, PA, 19426 �Anonymous� referees who goaded us into completing the Ranitidine story. Advertisements: Workshop on Frontiers of Powder Diffraction at the NSLS user meeting, May 19. nslsweb.nsls.bnl.gov. The International Centre for Diffraction Data is planning to run its third Pharmaceutical Powder X-ray Diffraction Symposium in 2004. See me to get on the mailing list, or browse www.icdd.com/ppxrd. References : Ashfia Huq and P.W. Stephens, �Subtleties in Crystal Structure solution from powder diffraction data using Simulated Annealing Method�, J. Pharm Sci. 92 244-249. Y.-H. Kiang, Ashfia Huq, Peter W. Stephens, Wei Xu, �Structure Determination of Enalapril Maleate Form II from High-Resolution X-ray Powder Diffraction Data,� submitted to Journal Pharm. Sci. Pagola S. and P.W.Stephens, Mater. Sci. Forum 2000, 321, 40 (Source code and documentation for PSSP are available at http://powder.physics.sunysb.edu)

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