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The Crash of HIV: Unraveling the Mystery behind CD4+ Cell Decline

Explore the impact of mutations in the GP-120 gene on CD4+ count decline in HIV-infected individuals. Analyze genetic variations and their association with disease progression. Utilize data from scientific studies to investigate the mechanisms influencing HIV pathogenesis.

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The Crash of HIV: Unraveling the Mystery behind CD4+ Cell Decline

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  1. The Crash!!!!HIV-The Silent Killer • SanjuktaHota • Alexandria Randriamahefa • ArlinToro LOGO LOGO Subject 12 -visit 5 RESULTS Subject 1 BACKGROUND • CD4+ count • Healthy person 800-1,200/mm3 of blood • AIDS <200/mm3 of blood HYPOTHESIS Data from Markham, et al. 1998GP-120 sequence data GP-120 CD$ Antibody RESULTS Subject 15 CONCLUSIONS Drasticdecline in CD4+ counts are caused by the mutations in the GP-120 gene. When comparing the subjects 1 and 15 with drastic decline in CD4 counts with the non progressor, they have a substitution of Aspartic acid (D) to Asparagine (N) in the 280th position of the amino acid sequence. MATERIALS AND METHODS BIBLIOGRAPHY Bioquest HIV Problem Set Protein Data Bank Swiss-Pdb Viewer Biology Workbench Microbes Coutnt Markham, et al., 1998 Data Set Protein Data Bank Swiss-Pdb Viewer Biology Workbench

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