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Inhibition of Murein Biosynthesis Tutorial

Inhibition of Murein Biosynthesis Tutorial. by. Willie Claiborne Brown, Ph.D. Professor Emeritus University of California, San Diego January, 2001. WCB. Sequence of Events inMurein Biosynthesis. NAG. NAG. NAG. NAG. NAG. NAG. NAG. NAG. NAG. NAG. NAG. NAG. NAG. P. UDP. NAM. P.

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Inhibition of Murein Biosynthesis Tutorial

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  1. Inhibition of Murein Biosynthesis Tutorial by Willie Claiborne Brown, Ph.D. Professor Emeritus University of California, San Diego January, 2001 WCB

  2. Sequence of Events inMurein Biosynthesis NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG P UDP NAM P NAM P-P Bactoprenol Bactoprenol Bactoprenol Section of Growing Murein NAM NAM Bactoprenol P NAM NAM P-P Bactoprenol P-P NAM UDP NAM 6 5 ATP Cytoplasm [Alanine Branch] 7 ATP ATP 2-4 ATP ATP 1 UDP P UMP 9 8 13 Membrane 10 11 12 14 Exterior WCB [Crosslinking Step]

  3. WCB Effect of D-Cycloserine on Murein Biosynthesis NAG NAG NAG NAG NAG NAG Section of Growing Murein NAM NAM NAM UDP NAM 5 Cytoplasm [Alanine Branch] 7 ATP 2-4 ATP ATP 1 9 8 13 Membrane 10 11 12 14 Exterior [Crosslinking Step]

  4. Effect of Bacitracin on Murein Biosynthesis NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG P UDP NAM P NAM P-P Bactoprenol Bactoprenol Bactoprenol Section of Growing Murein NAM NAM Bactoprenol P NAM NAM P-P Bactoprenol P-P NAM UDP NAM 6 5 ATP Cytoplasm [Alanine Branch] 7 ATP ATP 2-4 ATP ATP 1 UDP UMP 9 8 13 Membrane 10 11 12 14 Exterior WCB [Crosslinking Step]

  5. Effect of Beta Lactam Antibiotics onMurein Biosynthesis NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG P UDP NAM P NAM P-P Bactoprenol Bactoprenol Bactoprenol Section of Growing Murein NAM NAM Bactoprenol P NAM NAM P-P Bactoprenol P-P NAM UDP NAM 6 5 ATP Cytoplasm [Alanine Branch] 7 ATP ATP 2-4 ATP ATP 1 UDP P UMP 9 8 13 Membrane 10 11 12 14 WCB Exterior [Crosslinking Step]

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