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Murein Biosynthesis Tutorial

This tutorial by Dr. Willie Claiborne Brown, Professor Emeritus at the University of California, San Diego, explores the intricate process of murein (peptidoglycan) biosynthesis. It details the formation of crucial components such as N-Acetylglucosamine (NAG) and N-Acetylmuramic acid (NAM), along with the roles of amino acids and energy molecules like ATP and UTP. The tutorial outlines each step involved in murein assembly and crosslinking, providing insights into the biochemical pathways that sustain bacterial cell wall integrity. Ideal for students and researchers in microbiology and biochemistry.

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Murein Biosynthesis Tutorial

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  1. Murein Biosynthesis Tutorial by Willie Claiborne Brown, Ph.D. Professor Emeritus University of California, San Diego January, 2001

  2. NAG UDP NAM UDP Legend Uridine Diphosphate-N-Acetyl Glucosamine Uridine Diphosphate-N-Acetylmuramic Acid L-Alanine D-Glutamic Acid Dibasic Amino Acid D-Alanine D-Alanine Tri-Alanine Peptide Bactoprenol Carrier Lipid-Derivative of a C-55 Polyisoprenoid Alcohol

  3. Formation of Amino Sugars NAG UDP NAM UDP Fructose-6-P Glutamine(NH2) Acetyl CoA N-Acetylglucosamine(NAG) UTP P Phosphoenol Pyruvate(Lactyl) Reduction Steps Other Cell Reactions Murein Biosynthesis

  4. Sequence of Events inMurein Biosynthesis NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG P UDP NAM P NAM P-P Bactoprenol Bactoprenol Bactoprenol NAM NAM Bactoprenol NAM NAM P-P Bactoprenol P-P NAM UDP NAM 6 5 ATP Cytoplasm [Alanine Branch] 7 ATP ATP 2-4 ATP ATP 1 UDP P UMP 9 P 8 13 Membrane 10 Section of Growing Murein 11 12 14 [Crosslinking Step] Exterior

  5. Sequence of Events inMurein Biosynthesis NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG NAG P UDP NAM P NAM P-P Bactoprenol Bactoprenol Bactoprenol Section of Growing Murein NAM NAM Bactoprenol P NAM NAM P-P Bactoprenol P-P NAM UDP NAM 6 5 ATP Cytoplasm [Alanine Branch] 7 ATP ATP 2-4 ATP ATP 1 UDP P UMP 9 8 13 Membrane 10 11 12 14 Exterior [Crosslinking Step]

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