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Impact of Type 2 Diabetes on Brain Atrophy and Cognition

Explore the regional distribution of brain atrophy in Type 2 Diabetes and its influence on cognitive function. This study examines the association between T2DM, cerebral atrophy, and cognitive impairment using MRI scans and cognitive tests on 350 T2DM participants compared to 363 without T2DM. Results show T2DM linked with cerebral infarcts, reduced gray and white matter volumes, especially in specific brain regions, impacting visuospatial abilities, memory, and speed. The study suggests cortical atrophy in T2DM resembles patterns seen in early Alzheimer's disease, indicating neurodegeneration as a key factor in cognitive decline.

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Impact of Type 2 Diabetes on Brain Atrophy and Cognition

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  1. Featured Article: Brain Atrophy in Type 2 Diabetes Regional distribution and influence on cognition Chris Moran, M.B., B.C.H., Thanh G. Phan, P.H.D., Jian Chen, M.E., Leigh Blizzard, P.H.D., Richard Beare, P.H.D, Alison Venn, P.H.D., Gerald Münch, P.H.D., Amanda G. Wood, P.H.D., Josephine Forbes, P.H.D., Timothy M. Greenaway, P.H.D., Susan Pearson, P.H.D., Velandai Srikanth, P.H.D. Diabetes Care Volume 36: 4036-4042 December, 2013

  2. STUDY OBJECTIVE • Type 2 diabetes (T2DM) is associated with brain atrophy and cerebrovascular disease • We define the regional distribution of brain atrophy in T2DM and examine if atrophy or cerebrovascular lesions are links between T2DM and cognitive function Moran C. et al. Diabetes Care 2013;36:4036-4042

  3. STUDY DESIGN AND METHODS • Magnetic resonance imaging (MRI) scans and cognitive tests were used in 350 participants with T2DM and 363 participants without T2DM • With voxel-based morphometry, regional distribution of atrophy in T2DM was studied • Cerebrovascular lesions and atrophy were measured while blinded to T2DM status Moran C. et al. Diabetes Care 2013;36:4036-4042

  4. RESULTS • T2DM was associated with more cerebral infarcts and lower total gray, white, and • hippocampal volumes but not with microbleeds or white matter hyperintensity • T2DM-related gray matter loss was distributed mainly in medial temporal, anterior cingulate, and medial frontal lobes • White matter loss was distributed in frontal and temporal regions • T2DM was associated with poorer visuospatial construction, planning, visual memory, and speed independent of age, sex, education, and vascular risk factors Moran C. et al. Diabetes Care 2013;36:4036-4042

  5. Moran C. et al. Diabetes Care 2013;36:4036-4042

  6. Moran C. et al. Diabetes Care 2013;36:4036-4042

  7. CONCLUSIONS • Cortical atrophy in T2DM resembles patterns seen in preclinical Alzheimer disease • Neurodegeneration rather than cerebrovascular lesions may play a key role in T2DM-related cognitive impairment Moran C. et al. Diabetes Care 2013;36:4036-4042

  8. Moran C. et al. Diabetes Care 2013;36:4036-4042

  9. Moran C. et al. Diabetes Care 2013;36:4036-4042

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