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Drug Forms

Drug Forms. Peter Johnson SCHIN, Newcastle, UK Work done in Prodigy 3 project By Chris Wroe, Medical Informatics Group, Manchester University, UK. Motivation. Decision support Chronic disease management guidelines Computer needs to be able to answer questions such as :-

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Drug Forms

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  1. Drug Forms Peter Johnson SCHIN, Newcastle, UK Work done in Prodigy 3 project By Chris Wroe, Medical Informatics Group, Manchester University, UK

  2. Motivation • Decision support • Chronic disease management guidelines • Computer needs to be able to answer questions such as :- • “Is this patient on an inhaled steroid for asthma?” • “on a sustained release tablet for angina?” • Implies machine has explicit categorisation of drugs by Indication, Chemical structure, Route of admin, Form, etc.

  3. Patient on • Becodisks • Dry powder for inhalation, disks containing 8 blisters of beclometasone dipropionate • 100 micrograms/blister

  4. Forms proposed Spray.  Dermal Spray.  Inhalant.  .  Inhalant Powder.  .  .  Inhalant Powder Capsule.  .  Nasal Inhalant.  .  Oral Inhalant.  Nasal Spray.  Spray with Adaptor.  Powder Spray.  .  Inhalant Powder.  .  .  Inhalant Powder Capsule

  5. Inhaledsteroid for asthma Route – implies some forms Aerosol, Dry powder Drug class Indication

  6. Route of administration Physical Form + Administration Action + Administration Device Inhaled Powder Form for chewing Delivered by applicator ‘Form’ in reality

  7. Route taxonomy . topical to conjunctiva . topical to ear . topical to nose . topical to skin . topical to scalp . topical to oral mucosa . . buccal . sublingual . topical to teeth . oral (passing through oral cavity) . rectal . vaginal . intravenous . intrathecal . intraperitoneal . inhaled to lung . . inhaled to lung via nose . . inhaled to lung via mouth

  8. Drug form taxonomy . aerosol . bar . cake . disk . foam . gel . . jelly . gum . liniment . liquidEmulsion . lotion . ointment . particulate . . bead . . crystal . . flake . . granule . . pellet . . powder . . suppository . paste . patch . pillShaped . . caplet . . capsule . . tablet . . . lozenge . . . pastille . . troche . semiSolidEmulsion . . cream . solution . . aqueous . . . elixir . . . syrup . . oil . stick . suspension . wafer

  9. Device taxonomy . spray device . drug applicator . drug dropper device

  10. Process/Action taxonomy .Douching . Rinsing . Irrigating . Spraying . Liquid installing . . Infusing . . Irrigating . Chewing . Inhaling . Ingesting

  11. By Route . 'inhaled to lung form' . . 'Inhalation Solution' . . 'Nasal Inhalant' . . 'Oral Inhalant' . . 'Inhalant Powder' . . . 'Inhalant Powder Capsule‘ By Action By Physical Form . 'Solid' . . 'Powder' . . . 'Powder Spray' . . . . 'Inhalant Powder' . . . . . 'Inhalant Powder Capsule' . . . 'Powder for Reconstitution‘ By Device 4 hierarchies of ‘form’

  12. 'Sustained Release Buccal Tablet' Intermediate Representation : MAIN tabletHAS_PHARMACOKINETICS sustained releaseHAS_ROUTE buccal 

  13. Form classification: 'Solid‘ . 'Pill‘ . . 'Tablet‘ . . . 'Sustained Release Buccal Tablet' From form taxonomy: pillShaped  .  . caplet  .  . capsule  .  . tablet  .  .  . lozenge  .  .  . pastille  .  . troche   'Sustained Release Buccal Tablet'First parent :Form classification

  14. Route classification . 'oral mucosa form'. . 'buccal form'. . .'Sustained Release Buccal Tablet' From route taxonomy Route. topical to conjunctiva. topical to ear. topical to nose. topical to skin. topical to scalp. topical to oral mucosa. . buccal 'Sustained Release Buccal Tablet’ second parent : Route classification n.b. Pharmacokinetics – sustained release is another classification concept

  15. Preliminary work Quick classification of the leaf terms supplied Intermediate nodes from Prodigy work Chris Wroe [wroec@cs.man.ac.uk] http://www.cs.man.ac.uk/mig/people/wroec/index.html Where now?

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