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Therapeutic Applications of Treg Cells in Mouse Models of Human Diseases

Explore the regulation and therapeutic potential of Treg cells in immune-related diseases using Foxp3-transduced Th cells in mouse models. Discover how these cells suppress inflammatory bowel diseases, multiple sclerosis, and allergic asthma.

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Therapeutic Applications of Treg Cells in Mouse Models of Human Diseases

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  1. Contact Information: E-mail: zengw@marshall.edu Tel: 304 696-3892

  2. Regulation of Th Cell Subset Differentiation

  3. Cell Lineage Plasticity of Treg Cells

  4. Therapeutic Application of Treg Cells Therapeutic application of Foxp3-transduced Th cells in mouse models of human diseases. Left, inflammatory bowel diseases (massive inflammatory infiltration in the colon) were induced by adoptive transfer of CD25-CD45RBh conventional CD4 T cells to immune deficient mice. However, co-transfer of Foxp3-transduced Th1 or Th17 cells greatly alleviate the diseases. Center and right, similarly, Foxp3-transduced Th cells suppressed disease development in the mouse models of multiple sclerosis and allergic asthma, respectively.

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