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Do Now. Explain the difference between transcription and translation. (Hint: Think about what is made) Explain difference between codon and anticodon . 3. After answering the above questions get out a piece of scratch paper. What is the protein for the DNA strand below?.

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    Presentation Transcript
    1. Do Now • Explain the difference between transcription and translation. (Hint: Think about what is made) • Explain difference between codon and anticodon. 3. After answering the above questions get out a piece of scratch paper.

    2. What is the protein for the DNA strand below? TAATACAGGTTGCGTACT AUUAUGUCCAACGCAUGA DNA TRANSCRIPTION RNA TRANSLATION MET SER ASN ALA STOP

    3. Protein Synthesis Review Video

    4. Mutations Mutations

    5. What is a mutation? Change in the DNA nitrogen base sequence of a gene

    6. How do Mutations Occur? Errors in DNA Replication Replication

    7. How do Mutations Occur? Damaged DNA caused by agents such as sunlight, smoke, radiation

    8. How do we get mutations????

    9. Two ways to classify mutations Acquired mutation Get a mutation at some point in life. Hint: Think of it like getting sick, but you can’t get rid of it.

    10. Two ways to classify mutations Inherited mutation Get a mutation from your parents

    11. Let’s practice protein synthesis with normal DNA DNA: TAC AAC GTC ACC ATT mRNA: AUG UUG CAG UGG UAA Amino acid: Met Leu Gln Trp STOP

    12. Category of Mutation: Point Change in one base of the DNA sequence. Original: The fat cat ate the wee rat Point mutation: The fat hat ate the wee rat

    13. Example of Point Mutation: Sickle Cell Anemia

    14. Sickle Cell Anemia: Point Mutation

    15. Sickle Cell Anemia Story (Beginning to 3:00)

    16. Category of Mutation: Frameshift Addition or deletion of a DNA base resulting in a different sequence of DNA. Original: The fat cat ate the wee rat Frameshift mutation: The fat ata tet hew eer at

    17. Example of Frameshift Mutation: Tay Sachs

    18. Tay Sachs Symptoms: Video

    19. Tay Sachs Disease: Frameshift Mutation

    20. Type of Mutations: Missense Change in one base of the DNA sequence which causes a change in amino acid.

    21. Mutated Example of Missense DNA: TAC AAG GTC ACC ATT mRNA: AUG UUC CAG UGG UAA Amino acid: Met Phe Gln Trp STOP

    22. Type of Mutations: Nonsense Change in one base of the DNA sequence which codes for a STOP codon

    23. Mutated Example of Nonsense DNA: TAC AAC GTC ACT ATT mRNA: AUG UUG CAG UGA UAA Amino acid: Met Phe Gln STOP

    24. Type of Mutations: Silent Change in one base of the DNA sequence which has no effect on the amino acid sequence

    25. Mutated Example of Silent DNA: TAC AAT GTC ACC ATT mRNA: AUG UUA CAG UGG UAA Amino acid: Met Leu Gln Trp STOP

    26. Type of Mutations: Insertion Addition of one or more bases into a DNA sequence

    27. Mutated Example of Insertion DNA: TAC AAC CGT CAC CAT T mRNA: AUG UUG GCA GUG GUA A Amino acid: Met Leu Gly Val Val

    28. Type of Mutations: Deletion The removal of one or more bases in DNA

    29. Mutated Example of Deletion DNA: TAC AAC GCA CCA TT mRNA: AUG UUG CGA GGU AA Amino acid: Met Leu Arg Gly

    30. Blame it on DNA: Review Song