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Examining the Role of SHH and WNT Signaling Pathways in Group 3 and 4 Medulloblastoma

This study investigates the impact of SHH and WNT signaling in Group 3 and 4 medulloblastoma subtypes. Results from Supplemental Figures 1 to 3 show significant associations between these pathways and tumor progression, highlighting potential therapeutic targets.

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Examining the Role of SHH and WNT Signaling Pathways in Group 3 and 4 Medulloblastoma

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  1. Supplemental Fig. 1 p= 0.036 p= 0.29 p= 0.30 p= 0.77

  2. Supplemental Fig. 2 p= 1.8 x10-10 p= 6.9 x10-9 Group 3 Group 4 SHH WNT Group 3 Group 4 SHH WNT p= 6.58 x 10-6 p= 0.0002 Group 3 Group 4 SHH WNT Group 3 Group 4 SHH WNT p= 0.001 p= 0.44 Group 3 Group 4 SHH WNT Group 3 Group 4 SHH WNT

  3. Supplemental Fig. 3 p= 0.001 p= 1.6 x10-6 Group 3 Group 4 SHH WNT Group 3 Group 4 SHH WNT p= 8.6 x10-4 p= 7.5 x10-6 Group 3 Group 4 SHH WNT Group 3 Group 4 SHH WNT p= 2.6 x10-7 p= 9.9 x10-6 Group 3 Group 4 SHH WNT Group 3 Group 4 SHH WNT

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