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Urine Microscopy. + Dr. Mohammed Iqbal Musani, MD. Urine Microscopy :. Cells Casts Crystals . Casts are formed within nephron. Casts Suggest Kidney pathology. Casts can be made up of Protein, lipid, cells or mixed. Crystals suggest high concentration or altered solubility. .

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urine microscopy

Urine Microscopy

+Dr. Mohammed Iqbal Musani, MD

urine microscopy2
Urine Microscopy :
  • Cells Casts Crystals.
  • Casts are formed within nephron.
  • Casts Suggest Kidney pathology.
  • Casts can be made up of Protein, lipid, cells or mixed.
  • Crystals suggest high concentration or altered solubility.
white blood cell cast
White blood cell cast
  • Seen in interstitial disease most commonly
  • Also seen in glomerulonephritis
waxy cast
Waxy cast
  • Thought to result from the degeneration of cellular casts
non renal epithelial cells
Non-renal epithelial cells
  • Uro-epithelium is columnar
    • If there are a lot of these it means there is sloughing of the system
  • Skin is squamous
    • If there are a lot of squamous it is a contaminated specimen
so what is a cast
So…what is a cast???
  • Protein based cylindrical molds of the renal tubule
  • Form in distal tubules and collecting ducts
  • Result of damage to the renal tubule
  • Can contain cells and other material
  • Dehydration and acidic urine especially predisposes to cast formation
red cell cast
Red cell cast
  • Almost always associated with glomerulonephritis or vasculitis
  • Virtually exclude extra-renal causes of bleeding
granular cast
Granular cast
  • Non-specific but usually pathologic
  • Usually the ‘granules’ are from the degeneration of cellular casts
white blood cell cast50
White blood cell cast
  • Seen in interstitial disease most commonly
  • Also seen in glomerulonephritis
waxy cast53
Waxy cast
  • Thought to result from the degeneration of cellular casts
non renal epithelial cells54
Non-renal epithelial cells
  • Uro-epithelium is columnar
    • If there are a lot of these it means there is sloughing of the system
  • Skin is squamous
    • If there are a lot of squamous it is a contaminated specimen