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Gastrointestinal Balance: Do you have the guts for health?

Gastrointestinal Balance: Do you have the guts for health?. Mark Pettus MD March 8, 2018. The Epigenome How are “ Book of Life ” is interpreted and ultimately written. Disease (how things appear)

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Gastrointestinal Balance: Do you have the guts for health?

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  1. Gastrointestinal Balance: Do you have the guts for health? Mark Pettus MD March 8, 2018

  2. The Epigenome How are “Book of Life” is interpreted and ultimately written.

  3. Disease (how things appear) Pre-diabetes, Diabetes, Obesity, Metabolic Syndrome, Heart Disease, Stroke, Depression, Autoimmunity, Cognitive decline-Alzheimer’s, Cancer Core Metabolic Imbalances (what drives them) Inflammation Intestinal permeability-microbiome Root Causes (what are their origins) Gene-Environment-Compatability Nutrition Movement Stress Response Environmental toxins Sleep Social Connection Trauma Conflict Management Light Quality Stress Management Meaning in Work, Love, Play

  4. H E A L T H S P A N Decline in our food quality Loss of Diversity of our gut microbiome

  5. Problems with gut health can promote/worsen… • Allergy • Weight Gain • Asthma • Autoimmunity • Arthritis • Metabolic Bone disease • Skin problems • Mood disorders • Dementia • Cancer • Inflammation

  6. Increased Intestinal Permeability And molecular trafficking

  7. Common causes of increased intestinal permeability • SAD: Carbohydrate dense, high-sugar, low-fiber, processed diet; • Overuse of medications such as NSAIDs, antibiotics, acid blockers, steroids e.g. prednisone, chemotherapy • Food sensitivities – allergies e.g. gluten and casein • Low-grade bug imbalances (dysbiosis) involving yeast, bacterial overgrowth (SIBO) • Toxins e.g. BPA, pthalates, pesticide residues, glyphosate (GMO) • Stress or the brain-gut connection • Alcohol

  8. GI Disruptors • Antibiotics (prescription and agri-production) • NSAIDs • Proton-Pump Inhibitors • Insufficient fermentable fiber • GMO foods; glyphosate • Toxins e.g. petrochemicals, plastics, packaging, cosmetics, teflon, herbicides, preservatives e.g. BHT, BHA • Blue light

  9. Lectins • Highly evolved plant defense proteins • Whole grains, nightshades, beans, legumes, seeded veggies, unripened fruits/veggies • Enhance gut permeability • Elicit inflammatory response • Disrupt cell signaling, receptor function, endocrine disruption • Examples include WGA, gluten, A1-beta casein • WGA mimics insulin • Additive impact with altered microbiome, stress, sleep, medications, etc. • Strong effect on inflammatory and auto-immune conditions

  10. Carbohydrate-dense foods Major contributor of obesity, insulin resistance, changes in blood lipids, inflammation, and alterations of the organisms in the human microbiome A huge area of opportunity in individuals with increased belly fat, pre-diabetes or diabetes…these are health features of carbohydrate intolerance. For most, sugar and refined, grain-based foods are problematic: eliminate and observe.

  11. High-Quality Plant-Based Carbs Sugar, Fructose and Carbohydrate-Dense Grains Oral and Gut Microbiome Inflammation Neurotransmitters Insulin Resistance Weight and Metabolism Mitochondria-Oxidative stress HPA axis –Stress Response Protection from: Inflammation Diabetes Cancer Obesity

  12. Noteworthy contributions to alterations of the human microbiome • Dietary changes e.g. refined, processed simple starches and sugars “carbohydrate-dense” foods • C-sections • Formula feeding • Marked decreases in fermentable fiber • Antibiotic use in prescriptions and in industrialized foods • Glyphosate as an anti-microbial • Hygiene hypothesis • Prior GI infections; H. pylori; systemic infections SIBO-small intestinal bacterial overgrowth • Medications e.g. PPIs, steroids, chemotherapy

  13. Remove • Foods that one may be intolerant to (elimination diet: • start with gluten and dairy). • Medications that may negatively influence an optimal • GI environment (such as PPIs, H2 blockers, NSAIDs, • antibiotics, steroids). • For IBS or persistent dyspepsia, consider SIBO and • treat with xifaxin 200 mg, two tabs twice daily for • 10-14 days with neomycin • Consider a 2-4 week trial with Diflucan for yeast • Stress: how we interpret and respond

  14. Replace For persistent dyspepsia, indigestion, or long-term use of stomach acid suppression consider digestive enzymes to promote better macronutirent breakdown. These are usually plant-based (papaya, pineapple) compounds e.g. bromelain taken with each meal.

  15. Re-populate • Administer probiotics from the following three families that have been found to be beneficial for GI function: Bifidobacteria, Lactobacilli, and Saccharomyces. • Administer prebiotics (food that promotes beneficial bacterial growth) such as, plant-based fermentable fiber e.g. Jerusalem artichoke, onions, asparagus and garlic, cruciferous, resistant starch, leeks, berries. • Target at least 20-30 billion cfus/day

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