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Cytokine Signaling. Types of receptors . Protein tyrosine kinase receptors with intrinsic kinase activity Insulin, EGF, PDGF, CSF-1 etc. Protein serine kinase receptors with intrinsic kinase activity MIS, TGF b , activin, inhibin etc. Receptors without intrinsic kinase activity

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types of receptors
Types of receptors
  • Protein tyrosine kinase receptors with intrinsic kinase activity
    • Insulin, EGF, PDGF, CSF-1 etc.
  • Protein serine kinase receptors with intrinsic kinase activity
    • MIS, TGFb, activin, inhibin etc.
  • Receptors without intrinsic kinase activity
    • This is the large, heterogeneous group called the cytokine receptor super family
  • G-protein coupled receptors and ion-gated receptors
cytokine signaling mechanisms
Cytokine signaling mechanisms
  • Cytokines represent a diverse number of molecules.
  • The super family of cytokine receptors more specifically refers to those cytokines that signal via the Jak-STAT pathway
  • These include Interleukins 2, 3, 4, 5, 6, 7, 9, 11, 12, 13, & 15, and G-CSF, LIF and the interferons
  • In addition, growth hormone, prolactin, erythropoietin, leptin, thrombopoietin
  • Many growth factor signal pathways cross-communicate with the STAT pathway.
cytokines and leydig cells
Cytokines and Leydig cells

Immune-Endocrine control

of Leydig cell function

Overview and significance

of Immune-endocrine interactions

in the regulation of Leydig cell function