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This study by Naka et al. published in Nature emphasizes the critical requirement of TGF-β-Foxo signaling in maintaining the colony-forming capacity of leukemic stem cells. Understanding this mechanism holds significant implications for targeted leukemia therapies.
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TGF-–Foxo signalling is required for the colony-forming capacity of LICs. K Naka et al.Nature463, 676-680 (2010) doi:10.1038/nature08734