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Human Evolution: Past, Present & Future. London, 8-10th May 2013. Iodine , PUFAs and i odolipids in h ealth and disease : A n evolutionary perspective S Venturi 1 , CA Castellano 2,3 and SC Cunnane 2,3
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Iodine, PUFAs and iodolipidsin healthand disease: An evolutionaryperspective
S Venturi1, CA Castellano2,3 and SC Cunnane2,3
1Servizio di Igiene AUSL - Pennabilli (RN), Italy - Phone: 0541928205 - E-mail: firstname.lastname@example.org, 2Research Center on Aging, 3Depts of Medicine, Université de Sherbrooke, QC, Canada.
Figure 1 - Membrane Chemistry
Phospholipids contain one saturated and one unsaturated fatty acid.
Figure 2 Lipid language
The arachidonic acid pathway to
leukotrienes, prostaglandins, and thromboxanes.
Biodistribution of radio-iodine in the human
Sequence of 123-iodide total-body scintiscans of a woman after intravenous injection of 123-iodide (half-life: 13 h); (from left) respectively at 30 min, and 6, 20 and 48 h. The highest and most rapid concentration of radio-iodide is in stomach, salivary glands, CSF, choroid plexus and oral mucosa. In the thyroid, iodide is more progressive, as in a reservoir (from 1% after 30 min to 5.8 % after 48 h; Venturi, 2007).
Biodistribution of radio-iodine in the rat
Distribution of 131-iodine (half-life - 8 d) in autoradiographs of the rat after subcutaneous injection of 131-iodine. High I concentration is evident in iodo-compounds and iodo-lipids of the choroid plexus, retina, hypothalamus, gastric mucosa and epidermis, where it is detectable up to 5 days after injection (courtesy of Path Biol, 1961; Acta Radiol Ther Physics Biology, 1964).
(1) Venturi S. (2013). Iodine, PUFAs and iodolipids in health and diseases: an evolutionary perspective. Accepted for publication in Nutr Health
(2) Crawford, M. A. (2010). The language of lipids. In: Cunnane S, Stewart K, Eds. Human Brain Evolution, The Influence of Freshwater and Marine Food Resources. Wiley-Blackwell, NJ, 2010,: 13-28.
(3) Cunnane, S. (2010). Brain-Selective Nutrients. In: Cunnane S, Stewart K, Eds. Human Brain Evolution, The Influence of Freshwater and Marine Food Resources, Wiley-Blackwell , NJ, 2010: 33-61
(4) Küpper, F.C., Carpenter, L.J., McFiggans, G.B., et al. (2008). "Iodide accumulation provides kelp with an inorganic antioxidant impacting atmospheric chemistry". Proc. Natl. Acad. Sci. U.S.A. 105 (19): 6954–8.
(5) Packer, L. (2008). Oxidants and Antioxidants in Biology. XIV Biennial Meeting of the Society for Free Radical Research International; October 18-22, 2008. Beijing (China).*
(6) Venturi, S. (2011). Evolutionary Significance of Iodine. Current Chem. Biol., 5 ,3 :155-162.